Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies: A case report

Asami Ozaki, Masaki Nishida, Keiko Koyama, Kinya Ishikawa, Toru Nishikawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow-wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalPsychogeriatrics
Volume12
Issue number4
DOIs
Publication statusPublished - 2012 Dec
Externally publishedYes

Fingerprint

Lewy Body Disease
Sleep
Polysomnography
REM Sleep
Cholinesterase Inhibitors
Cognition
Cholinergic Agents
donepezil

Keywords

  • Acetylcholine
  • DLB
  • Donepezil
  • Polysomnography
  • Sleep spindle

ASJC Scopus subject areas

  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies : A case report. / Ozaki, Asami; Nishida, Masaki; Koyama, Keiko; Ishikawa, Kinya; Nishikawa, Toru.

In: Psychogeriatrics, Vol. 12, No. 4, 12.2012, p. 255-258.

Research output: Contribution to journalArticle

Ozaki, Asami ; Nishida, Masaki ; Koyama, Keiko ; Ishikawa, Kinya ; Nishikawa, Toru. / Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies : A case report. In: Psychogeriatrics. 2012 ; Vol. 12, No. 4. pp. 255-258.
@article{827d90ff0db248e18f72abaa2e828b9a,
title = "Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies: A case report",
abstract = "Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow-wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.",
keywords = "Acetylcholine, DLB, Donepezil, Polysomnography, Sleep spindle",
author = "Asami Ozaki and Masaki Nishida and Keiko Koyama and Kinya Ishikawa and Toru Nishikawa",
year = "2012",
month = "12",
doi = "10.1111/j.1479-8301.2012.00411.x",
language = "English",
volume = "12",
pages = "255--258",
journal = "Psychogeriatrics",
issn = "1346-3500",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies

T2 - A case report

AU - Ozaki, Asami

AU - Nishida, Masaki

AU - Koyama, Keiko

AU - Ishikawa, Kinya

AU - Nishikawa, Toru

PY - 2012/12

Y1 - 2012/12

N2 - Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow-wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.

AB - Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow-wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.

KW - Acetylcholine

KW - DLB

KW - Donepezil

KW - Polysomnography

KW - Sleep spindle

UR - http://www.scopus.com/inward/record.url?scp=84871845897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871845897&partnerID=8YFLogxK

U2 - 10.1111/j.1479-8301.2012.00411.x

DO - 10.1111/j.1479-8301.2012.00411.x

M3 - Article

C2 - 23279148

AN - SCOPUS:84871845897

VL - 12

SP - 255

EP - 258

JO - Psychogeriatrics

JF - Psychogeriatrics

SN - 1346-3500

IS - 4

ER -