Abstract
The capacity for goal-directed behavior requires not only the encoding of the response-outcome relationship but also the ability to resolve conflict induced by competing responses. Recent neuroimaging studies have identified the prefrontal cortex as critical for resolving conflict between competing responses. At present, however,muchof this evidence is indirect, and the necessity of dorsomedial prefrontal cortex (dmPFC) function for the resolution of conflict in goal-directed behavior has not been assessed. Here, we develop a rodent paradigm to investigate response conflict caused by the concurrent activation of a correct and incorrect response. In this paradigm, the outcome of one response also acts as a discriminative stimulus signaling that the other response is correct. Whereas rats with a functional dmPFC are able to resolve this conflict, inactivation of dmPFC using an infusion of muscimol produced a deficit by selectively interfering with their ability to inhibit the incorrect, competing response.
| Original language | English |
|---|---|
| Pages (from-to) | 5224-5229 |
| Number of pages | 6 |
| Journal | Journal of Neuroscience |
| Volume | 26 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
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Keywords
- Dorsomedial prefrontal cortex
- Goal-directed behavior
- Rat
- Response conflict
- Response inhibition
- Reversible lesion
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Dorsomedial prefrontal cortex resolves response conflict in rats. / De Wit, Sanne; Kosaki, Yutaka; Balleine, Bernard Walter; Dickinson, Anthony.
In: Journal of Neuroscience, Vol. 26, No. 19, 2006, p. 5224-5229.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dorsomedial prefrontal cortex resolves response conflict in rats
AU - De Wit, Sanne
AU - Kosaki, Yutaka
AU - Balleine, Bernard Walter
AU - Dickinson, Anthony
PY - 2006
Y1 - 2006
N2 - The capacity for goal-directed behavior requires not only the encoding of the response-outcome relationship but also the ability to resolve conflict induced by competing responses. Recent neuroimaging studies have identified the prefrontal cortex as critical for resolving conflict between competing responses. At present, however,muchof this evidence is indirect, and the necessity of dorsomedial prefrontal cortex (dmPFC) function for the resolution of conflict in goal-directed behavior has not been assessed. Here, we develop a rodent paradigm to investigate response conflict caused by the concurrent activation of a correct and incorrect response. In this paradigm, the outcome of one response also acts as a discriminative stimulus signaling that the other response is correct. Whereas rats with a functional dmPFC are able to resolve this conflict, inactivation of dmPFC using an infusion of muscimol produced a deficit by selectively interfering with their ability to inhibit the incorrect, competing response.
AB - The capacity for goal-directed behavior requires not only the encoding of the response-outcome relationship but also the ability to resolve conflict induced by competing responses. Recent neuroimaging studies have identified the prefrontal cortex as critical for resolving conflict between competing responses. At present, however,muchof this evidence is indirect, and the necessity of dorsomedial prefrontal cortex (dmPFC) function for the resolution of conflict in goal-directed behavior has not been assessed. Here, we develop a rodent paradigm to investigate response conflict caused by the concurrent activation of a correct and incorrect response. In this paradigm, the outcome of one response also acts as a discriminative stimulus signaling that the other response is correct. Whereas rats with a functional dmPFC are able to resolve this conflict, inactivation of dmPFC using an infusion of muscimol produced a deficit by selectively interfering with their ability to inhibit the incorrect, competing response.
KW - Dorsomedial prefrontal cortex
KW - Goal-directed behavior
KW - Rat
KW - Response conflict
KW - Response inhibition
KW - Reversible lesion
UR - http://www.scopus.com/inward/record.url?scp=33646936298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646936298&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.5175-05.2006
DO - 10.1523/JNEUROSCI.5175-05.2006
M3 - Article
C2 - 16687514
AN - SCOPUS:33646936298
VL - 26
SP - 5224
EP - 5229
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 19
ER -