Dorsomedial prefrontal cortex resolves response conflict in rats

Sanne De Wit*, Yutaka Kosaki, Bernard Walter Balleine, Anthony Dickinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)


The capacity for goal-directed behavior requires not only the encoding of the response-outcome relationship but also the ability to resolve conflict induced by competing responses. Recent neuroimaging studies have identified the prefrontal cortex as critical for resolving conflict between competing responses. At present, however,muchof this evidence is indirect, and the necessity of dorsomedial prefrontal cortex (dmPFC) function for the resolution of conflict in goal-directed behavior has not been assessed. Here, we develop a rodent paradigm to investigate response conflict caused by the concurrent activation of a correct and incorrect response. In this paradigm, the outcome of one response also acts as a discriminative stimulus signaling that the other response is correct. Whereas rats with a functional dmPFC are able to resolve this conflict, inactivation of dmPFC using an infusion of muscimol produced a deficit by selectively interfering with their ability to inhibit the incorrect, competing response.

Original languageEnglish
Pages (from-to)5224-5229
Number of pages6
JournalJournal of Neuroscience
Issue number19
Publication statusPublished - 2006
Externally publishedYes


  • Dorsomedial prefrontal cortex
  • Goal-directed behavior
  • Rat
  • Response conflict
  • Response inhibition
  • Reversible lesion

ASJC Scopus subject areas

  • Neuroscience(all)


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