Dose-dependent effects of diallyl disulfide on plasma glucose and free fatty acid levels in rats

Yoko Hashizume, Ken Shirato, Shogo Sato, Akiko Matsumoto, Kaoru Tachiyashiki, Kazuhiko Imaizumi

    Research output: Contribution to journalArticle

    Abstract

    The acute effects of oral administration of diallyl disulfide (DADS), the major organosulfur compound of garlic, on plasma glucose and free fatty acid (FFA) concentrations were examined in rats. Male, 10-week-old Sprague-Dawley rats were divided into DADS-free and DADS-administered (dose =10, 20, and 40 mg/kg body weight [BW]) groups. Plasma samples were prepared from whole blood drawn from the tail vein 0, 1,2, 4, and 6 hr after administration. The stomachs were isolated, and the contents were measured 8 hr after administration. In DADS-administered groups, plasma glucose concentrations were increased in a dose-dependent manner 1 hr after the administration. The increase was transient, except in groups administered 40 mg/kg BW of DADS, in which plasma glucose levels remained significantly higher than the DADS-free levels throughout the experimental period. Similar patterns were observed in the plasma FFA concentrations, although the significant differences were lower than those observed in the plasma glucose concentrations. The gastric contents were dose-dependently elevated after DADS administration. The increase was significant when 20 or 40 mg/kg BW of DADS was administered. These results suggest that oral administration of DADS can mobilize energy substrates into the blood, although a higher dose of DADS slows gastric emptying.

    Original languageEnglish
    Pages (from-to)879-884
    Number of pages6
    JournalJournal of Toxicological Sciences
    Volume38
    Issue number6
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Diallyl disulfide
    • Free fatty acids
    • Gastric emptying
    • Glucose

    ASJC Scopus subject areas

    • Toxicology

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  • Cite this

    Hashizume, Y., Shirato, K., Sato, S., Matsumoto, A., Tachiyashiki, K., & Imaizumi, K. (2013). Dose-dependent effects of diallyl disulfide on plasma glucose and free fatty acid levels in rats. Journal of Toxicological Sciences, 38(6), 879-884. https://doi.org/10.2131/jts.38.879