Drift and fluctuating motion of artificial platelets during the lateral transport and adhesion process near the wall

Hiroaki Tobimatsu, Antoine Paragon, Yosuke Okamura, Shinji Takeoka, Ryo Sudo, Yasuo Ikeda, Kazuo Tanishita

    Research output: Contribution to journalArticle

    Abstract

    Recombinant glycoprotein Ibα latex beads (rGPIbα-LB) are a potential solution to overcoming platelet transfusion problems with artificial platelets. To understand the transport process of artificial platelets and to estimate the particle motion when adhering to the wall surface, we evaluated the lateral motion of rGPIbα-LB in terms of drift and random motion, because the lateral motion is an important factor for transport and adhesion. We observed the lateral motion of rGPIbα-LB flowing with red blood cells toward the immobilized von Willebrand factor (vWf) surface in a model arteriole at wall shear rates of 200-1000 s-1 and 0-40% Hct. At 40% Hct, wall shear rate dependence was observed for the drift motion, i. e. the lateral velocity of rGPIbα-LB toward the wall. In the near-wall region, the drift motion of contacting particles differed substantially from that of non-contacting particles. Additionally, the trajectories of contacting particles on the vWf surface had specific motion that was not observed on the BSA surface. These results suggest that the adhesion force between rGPIbα and vWf is highly associated with the motion of particles near the wall. These features are desirable for artificial platelets, particularly for the adhesion process.

    Original languageEnglish
    Pages (from-to)11-20
    Number of pages10
    JournalJournal of Biorheology
    Volume26
    Issue number1-2
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Platelet Glycoprotein GPIb-IX Complex
    Glycoproteins
    Latex
    Platelets
    Latexes
    von Willebrand Factor
    Adhesion
    Shear deformation
    Blood
    Cells
    Trajectories

    Keywords

    • Adhesion
    • Blood flow
    • Glycoprotein Ibα
    • Lateral motion
    • Near-wall excess
    • von Willebrand factor

    ASJC Scopus subject areas

    • Mechanics of Materials
    • Materials Science(all)
    • Mechanical Engineering

    Cite this

    Drift and fluctuating motion of artificial platelets during the lateral transport and adhesion process near the wall. / Tobimatsu, Hiroaki; Paragon, Antoine; Okamura, Yosuke; Takeoka, Shinji; Sudo, Ryo; Ikeda, Yasuo; Tanishita, Kazuo.

    In: Journal of Biorheology, Vol. 26, No. 1-2, 2013, p. 11-20.

    Research output: Contribution to journalArticle

    Tobimatsu, Hiroaki ; Paragon, Antoine ; Okamura, Yosuke ; Takeoka, Shinji ; Sudo, Ryo ; Ikeda, Yasuo ; Tanishita, Kazuo. / Drift and fluctuating motion of artificial platelets during the lateral transport and adhesion process near the wall. In: Journal of Biorheology. 2013 ; Vol. 26, No. 1-2. pp. 11-20.
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    abstract = "Recombinant glycoprotein Ibα latex beads (rGPIbα-LB) are a potential solution to overcoming platelet transfusion problems with artificial platelets. To understand the transport process of artificial platelets and to estimate the particle motion when adhering to the wall surface, we evaluated the lateral motion of rGPIbα-LB in terms of drift and random motion, because the lateral motion is an important factor for transport and adhesion. We observed the lateral motion of rGPIbα-LB flowing with red blood cells toward the immobilized von Willebrand factor (vWf) surface in a model arteriole at wall shear rates of 200-1000 s-1 and 0-40{\%} Hct. At 40{\%} Hct, wall shear rate dependence was observed for the drift motion, i. e. the lateral velocity of rGPIbα-LB toward the wall. In the near-wall region, the drift motion of contacting particles differed substantially from that of non-contacting particles. Additionally, the trajectories of contacting particles on the vWf surface had specific motion that was not observed on the BSA surface. These results suggest that the adhesion force between rGPIbα and vWf is highly associated with the motion of particles near the wall. These features are desirable for artificial platelets, particularly for the adhesion process.",
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    AU - Sudo, Ryo

    AU - Ikeda, Yasuo

    AU - Tanishita, Kazuo

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