Drug delivery to bone marrow using surface-modified vesicles

Keitaro Sou, Eishun Tsuchida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An advantage of using vesicles (liposomes) as drug delivery carriers is that their pharmacokinetics can be controlled by surface characteristics, which can permit specific delivery of the encapsulated agents to organs or cells in vivo. We discovered a surface-modified vesicle which can target bone marrow through systemic circulation. This vesicle is a potent carrier to deliver therapeutic agents into bone marrow in treatment of hematopoietic disorders such as tumor and myelosuppression. In this report, we demonstrate that this surface-modified vesicle functions as carrier to deliver encapsulated agents into bone marrow.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages4865
Number of pages1
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama
Duration: 2006 Sep 202006 Sep 22

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CityToyama
Period06/9/2006/9/22

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Keywords

  • Bone marrow
  • Carrier
  • Drug delivery
  • Phospholipid vesicles
  • Surface modification

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sou, K., & Tsuchida, E. (2006). Drug delivery to bone marrow using surface-modified vesicles. In Polymer Preprints, Japan (2 ed., Vol. 55, pp. 4865)