Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream

Dhananjay Huilgol, Susan Udin, Tomomi Shimogori, Bhaskar Saha, Achira Roy, Shinichi Aizawa, Robert F. Hevner, Gundela Meyer, Toshio Ohshima, Samuel J. Pleasure, Yangu Zhao, Shubha Tole

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functional segregation in processing reproductive and defensive and aggressive behaviors, respectively. We observed a dichotomy in the development of the projection neurons of the aAOB and pAOB in mice. We found that they had distinct sites of origin and that different regulatory molecules were required for their specification and migration. aAOB neurons arose locally in the rostral telencephalon, similar to main olfactory bulb neurons. In contrast, pAOB neurons arose caudally, from the neuroepithelium of the diencephalic-telencephalic boundary, from which they migrated rostrally to reach their destination. This unusual origin and migration is conserved in Xenopus, providing an insight into the origin of a key component of this system in evolution.

    Original languageEnglish
    Pages (from-to)157-165
    Number of pages9
    JournalNature Neuroscience
    Volume16
    Issue number2
    DOIs
    Publication statusPublished - 2013 Feb

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    Olfactory Bulb
    Neurons
    Telencephalon
    Vomeronasal Organ
    Social Behavior
    Xenopus

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Huilgol, D., Udin, S., Shimogori, T., Saha, B., Roy, A., Aizawa, S., ... Tole, S. (2013). Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nature Neuroscience, 16(2), 157-165. https://doi.org/10.1038/nn.3297

    Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. / Huilgol, Dhananjay; Udin, Susan; Shimogori, Tomomi; Saha, Bhaskar; Roy, Achira; Aizawa, Shinichi; Hevner, Robert F.; Meyer, Gundela; Ohshima, Toshio; Pleasure, Samuel J.; Zhao, Yangu; Tole, Shubha.

    In: Nature Neuroscience, Vol. 16, No. 2, 02.2013, p. 157-165.

    Research output: Contribution to journalArticle

    Huilgol, D, Udin, S, Shimogori, T, Saha, B, Roy, A, Aizawa, S, Hevner, RF, Meyer, G, Ohshima, T, Pleasure, SJ, Zhao, Y & Tole, S 2013, 'Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream', Nature Neuroscience, vol. 16, no. 2, pp. 157-165. https://doi.org/10.1038/nn.3297
    Huilgol, Dhananjay ; Udin, Susan ; Shimogori, Tomomi ; Saha, Bhaskar ; Roy, Achira ; Aizawa, Shinichi ; Hevner, Robert F. ; Meyer, Gundela ; Ohshima, Toshio ; Pleasure, Samuel J. ; Zhao, Yangu ; Tole, Shubha. / Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. In: Nature Neuroscience. 2013 ; Vol. 16, No. 2. pp. 157-165.
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