Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

Masao Kamimura; Michiko Sugawara; Shota Yamamoto; Kazuo Yamaguchi; Jun Nakanishi

doi:10.1039/c6bm00100a

Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

Masao Kamimura, Michiko Sugawara, Shota Yamamoto, Kazuo Yamaguchi, Jun Nakanishi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.

Original language	English
Pages (from-to)	933-937
Number of pages	5
Journal	Biomaterials Science
Volume	4
Issue number	6
DOIs	https://doi.org/10.1039/c6bm00100a
Publication status	Published - 2016 Jun
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering
Materials Science(all)

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10.1039/c6bm00100a

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abstract = "A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.",

author = "Masao Kamimura and Michiko Sugawara and Shota Yamamoto and Kazuo Yamaguchi and Jun Nakanishi",

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AU - Sugawara, Michiko

AU - Yamamoto, Shota

AU - Yamaguchi, Kazuo

AU - Nakanishi, Jun

PY - 2016/6

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Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

Abstract

ASJC Scopus subject areas

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