Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

Masao Kamimura, Michiko Sugawara, Shota Yamamoto, Kazuo Yamaguchi, Jun Nakanishi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.

Original languageEnglish
Pages (from-to)933-937
Number of pages5
JournalBiomaterials Science
Volume4
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1
Externally publishedYes

Fingerprint

Cell adhesion
Stiffness
Substrates
Gels
Irradiation
Mechanical properties
Geometry

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

Cite this

Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration. / Kamimura, Masao; Sugawara, Michiko; Yamamoto, Shota; Yamaguchi, Kazuo; Nakanishi, Jun.

In: Biomaterials Science, Vol. 4, No. 6, 01.06.2016, p. 933-937.

Research output: Contribution to journalArticle

Kamimura, Masao ; Sugawara, Michiko ; Yamamoto, Shota ; Yamaguchi, Kazuo ; Nakanishi, Jun. / Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration. In: Biomaterials Science. 2016 ; Vol. 4, No. 6. pp. 933-937.
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