Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes

Kenichi Nagase, Ayaka Kimura, Tatsuya Shimizu, Katsuhisa Matsuura, Masayuki Yamato, Naoya Takeda, Teruo Okano

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Poly(N-isopropylacrylamide)(PIPAAm) brush with various brush lengths grafted glass surfaces were prepared as a cell separating intelligent interface through a surface-initiated atom transfer radical polymerization (ATRP) with a CuCl/Me6TREN catalytic system. Prepared PIPAAm brush surfaces as a cell separating intelligent interfaces were characterized by observing the adhesion and detachment behavior of four types of human cells. PIPAAm brush with a moderate brush length exhibited the different cell detachment rates among individual cell types. These results indicated that precisely designed PIPAAm brush functioned as an intelligent cell separating interface by utilizing the intrinsic cell detachment properties of individual cells.

    Original languageEnglish
    Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
    PublisherChemical and Biological Microsystems Society
    Pages1105-1107
    Number of pages3
    ISBN (Print)9780979806452
    Publication statusPublished - 2012
    Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa
    Duration: 2012 Oct 282012 Nov 1

    Other

    Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
    CityOkinawa
    Period12/10/2812/11/1

    Fingerprint

    Brushes
    Polymers
    Atom transfer radical polymerization
    Adhesion
    Cells
    Glass
    poly-N-isopropylacrylamide

    Keywords

    • Cell separation
    • Intelligent materials
    • Polymer brush
    • Regenerative medicine
    • Temperature-responsive polymer

    ASJC Scopus subject areas

    • Chemical Engineering (miscellaneous)
    • Bioengineering

    Cite this

    Nagase, K., Kimura, A., Shimizu, T., Matsuura, K., Yamato, M., Takeda, N., & Okano, T. (2012). Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1105-1107). Chemical and Biological Microsystems Society.

    Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes. / Nagase, Kenichi; Kimura, Ayaka; Shimizu, Tatsuya; Matsuura, Katsuhisa; Yamato, Masayuki; Takeda, Naoya; Okano, Teruo.

    Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. p. 1105-1107.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nagase, K, Kimura, A, Shimizu, T, Matsuura, K, Yamato, M, Takeda, N & Okano, T 2012, Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes. in Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, pp. 1105-1107, 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, Okinawa, 12/10/28.
    Nagase K, Kimura A, Shimizu T, Matsuura K, Yamato M, Takeda N et al. Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society. 2012. p. 1105-1107
    Nagase, Kenichi ; Kimura, Ayaka ; Shimizu, Tatsuya ; Matsuura, Katsuhisa ; Yamato, Masayuki ; Takeda, Naoya ; Okano, Teruo. / Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, 2012. pp. 1105-1107
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