Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes

Kenichi Nagase, Ayaka Kimura, Tatsuya Shimizu, Katsuhisa Matsuura, Masayuki Yamato, Naoya Takeda, Teruo Okano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Poly(N-isopropylacrylamide)(PIPAAm) brush with various brush lengths grafted glass surfaces were prepared as a cell separating intelligent interface through a surface-initiated atom transfer radical polymerization (ATRP) with a CuCl/Me6TREN catalytic system. Prepared PIPAAm brush surfaces as a cell separating intelligent interfaces were characterized by observing the adhesion and detachment behavior of four types of human cells. PIPAAm brush with a moderate brush length exhibited the different cell detachment rates among individual cell types. These results indicated that precisely designed PIPAAm brush functioned as an intelligent cell separating interface by utilizing the intrinsic cell detachment properties of individual cells.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1105-1107
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012 Jan 1
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

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Keywords

  • Cell separation
  • Intelligent materials
  • Polymer brush
  • Regenerative medicine
  • Temperature-responsive polymer

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Nagase, K., Kimura, A., Shimizu, T., Matsuura, K., Yamato, M., Takeda, N., & Okano, T. (2012). Dynamically cell separating thermo-responisive biointerfaces having dense polymer brushes. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1105-1107). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.