Dynamics of Z-form DNA

Ikuo Ashikawa; Kazuhiko Kinosita; Akira Ikegami

doi:10.1016/0167-4781(84)90109-X

Dynamics of Z-form DNA

Ikuo Ashikawa, Kazuhiko Kinosita, Akira Ikegami

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The torsional and bending rigidities of Z-form DNA have been studied by nanosecond fluorescence anisotropy measurements of intercalated ethidium. The results suggested that Z-form DNA was considerably more flexible than B-form DNA. We have investigated the temperature dependence of the rigidity of B- and Z-form DNA and found that the temperature dependence of the torsional rigidity of Z-form DNA was remarkably lower than that of B-form DNA.

Original language	English
Pages (from-to)	87-93
Number of pages	7
Journal	BBA - Gene Structure and Expression
Volume	782
Issue number	1
DOIs	https://doi.org/10.1016/0167-4781(84)90109-X
Publication status	Published - 1984 May 15
Externally published	Yes

Keywords

DNA dynamics
Ethidium bromide
Fluorescence anisotropy
Helix rigidity
Z-DNA

ASJC Scopus subject areas

Biochemistry
Biophysics
Genetics
Structural Biology

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AU - Ashikawa, Ikuo

AU - Kinosita, Kazuhiko

AU - Ikegami, Akira

PY - 1984/5/15

Y1 - 1984/5/15

N2 - The torsional and bending rigidities of Z-form DNA have been studied by nanosecond fluorescence anisotropy measurements of intercalated ethidium. The results suggested that Z-form DNA was considerably more flexible than B-form DNA. We have investigated the temperature dependence of the rigidity of B- and Z-form DNA and found that the temperature dependence of the torsional rigidity of Z-form DNA was remarkably lower than that of B-form DNA.

AB - The torsional and bending rigidities of Z-form DNA have been studied by nanosecond fluorescence anisotropy measurements of intercalated ethidium. The results suggested that Z-form DNA was considerably more flexible than B-form DNA. We have investigated the temperature dependence of the rigidity of B- and Z-form DNA and found that the temperature dependence of the torsional rigidity of Z-form DNA was remarkably lower than that of B-form DNA.

KW - DNA dynamics

KW - Ethidium bromide

KW - Fluorescence anisotropy

KW - Helix rigidity

KW - Z-DNA

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JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

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