Dynapenic obesity and prevalence of type 2 diabetes in Middle-Aged japanese men

Ryoko Kawakami, Susumu S. Sawada, I. Min Lee, Munehiro Matsushita, Yuko Gando, Takashi Okamoto, Koji Tsukamoto, Mitsuru Higuchi, Motohiko Miyachi, Steven N. Blair

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear. Methods: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 years. Weight and height were measured, and overweight/obesity was defined as a body mass index ≥25 kg/m2. The prevalence of type 2 diabetes, defined as fasting plasma glucose ≥126 mg/dL and/or hemoglobin A1c ≥6.5% and/or self-reported physician-diagnosed diabetes, was evaluated. Odds ratios (OR) and 95% confidence intervals (95% CI) for the prevalence of type 2 diabetes were obtained using a logistic regression model. Results: In total, 611 participants had type 2 diabetes, and 1763 participants were overweight/obese. After adjustment for covariates, we found an inverse association between muscle strength and the prevalence of type 2 diabetes (P for trend <0.01). In addition, when the analyses were stratified by obesity status, the multivariableadjusted OR per 2-standard-deviation increase in muscle strength was 0.64 (95% CI, 0.49-0.83) in the overweight/ obese group, compared to a weaker relationship in the normal-weight group (OR 0.79 per 2-standard-deviation increase; 95% CI, 0.60-1.06). Conclusions: Dynapenia, an age-related decrease in muscle strength, is associated with increased prevalence of type 2 diabetes, and this relationship is stronger in overweight/obese middle-aged Japanese men than in normalweight men.

Original languageEnglish
Pages (from-to)663-665
Number of pages3
JournalJournal of epidemiology
Volume25
Issue number10
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Body mass index
  • Dynapenia
  • Hand strength
  • Hyperglycemia
  • Muscle strength

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Dynapenic obesity and prevalence of type 2 diabetes in Middle-Aged japanese men'. Together they form a unique fingerprint.

  • Cite this

    Kawakami, R., Sawada, S. S., Lee, I. M., Matsushita, M., Gando, Y., Okamoto, T., Tsukamoto, K., Higuchi, M., Miyachi, M., & Blair, S. N. (2015). Dynapenic obesity and prevalence of type 2 diabetes in Middle-Aged japanese men. Journal of epidemiology, 25(10), 663-665. https://doi.org/10.2188/jea.JE20150299