Early-life stress induces cognitive disorder in middle-aged mice

Hiroyuki Yajima, Asahi Haijima, Miski Aghnia Khairinisa, Noriaki Shimokawa, Izuki Amano, Yusuke Takatsuru

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Early-life stress can induce several neuropsychological disorders in adulthood. However, the underlying mechanisms inducing such disorders are still not fully understood. Furthermore, the effects of early-life stress on the changes in cognitive function with age are still not clarified. In this study, we used maternal deprivation (MD) to examine the cognitive function in middle-aged mice using a touchscreen-equipped operant chamber. In the visual-discrimination task, the aged (∼1.4 years old) control mice could accurately learn to discriminate between different visual stimuli. In contrast, the correct response rate of aged MD mice increased to ∼60% by day 10; it was still significantly lower than that of the control mice (85%). In the hippocampus of aged MD mice, the expression level of the N-methyl-d-aspartate receptor subunit GluN1 decreased significantly as compared to that in control mice. On the other hand, no significant difference in GluN1 expression level was detected in young (2.5 months old) mice. These findings indicate that early-life stress accelerates cognitive impairment in middle-aged mice.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalNeurobiology of Aging
Volume64
DOIs
Publication statusPublished - 2018 Apr
Externally publishedYes

Fingerprint

Psychological Stress
Maternal Deprivation
Cognition
Hippocampus

Keywords

  • Aging
  • Behavioral and cognitive neuroscience
  • Maternal deprivation
  • NMDA receptor
  • Touch panel operant task

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Yajima, H., Haijima, A., Khairinisa, M. A., Shimokawa, N., Amano, I., & Takatsuru, Y. (2018). Early-life stress induces cognitive disorder in middle-aged mice. Neurobiology of Aging, 64, 139-146. https://doi.org/10.1016/j.neurobiolaging.2017.12.021

Early-life stress induces cognitive disorder in middle-aged mice. / Yajima, Hiroyuki; Haijima, Asahi; Khairinisa, Miski Aghnia; Shimokawa, Noriaki; Amano, Izuki; Takatsuru, Yusuke.

In: Neurobiology of Aging, Vol. 64, 04.2018, p. 139-146.

Research output: Contribution to journalArticle

Yajima, H, Haijima, A, Khairinisa, MA, Shimokawa, N, Amano, I & Takatsuru, Y 2018, 'Early-life stress induces cognitive disorder in middle-aged mice', Neurobiology of Aging, vol. 64, pp. 139-146. https://doi.org/10.1016/j.neurobiolaging.2017.12.021
Yajima H, Haijima A, Khairinisa MA, Shimokawa N, Amano I, Takatsuru Y. Early-life stress induces cognitive disorder in middle-aged mice. Neurobiology of Aging. 2018 Apr;64:139-146. https://doi.org/10.1016/j.neurobiolaging.2017.12.021
Yajima, Hiroyuki ; Haijima, Asahi ; Khairinisa, Miski Aghnia ; Shimokawa, Noriaki ; Amano, Izuki ; Takatsuru, Yusuke. / Early-life stress induces cognitive disorder in middle-aged mice. In: Neurobiology of Aging. 2018 ; Vol. 64. pp. 139-146.
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