Eating meals before wheel-running exercise attenuate high fat diet-driven obesity in mice under two meals per day schedule

Hiroyuki Sasaki, Yuta Hattori, Yuko Ikeda, Mayo Kamagata, Shigenobu Shibata

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Mice that exercise after meals gain less body weight and visceral fat compared to those that exercised before meals under a one meal/exercise time per day schedule. Humans generally eat two or three meals per day, and rarely have only one meal. To extend our previous observations, we examined here whether a "two meals, two exercise sessions per day" schedule was optimal in terms of maintaining a healthy body weight. In this experiment, "morning" refers to the beginning of the active phase (the "morning" for nocturnal animals). We found that 2-h feeding before 2-h exercise in the morning and evening (F-Ex/F-Ex) resulted in greater attenuation of high fat diet (HFD)-induced weight gain compared to other combinations of feeding and exercise under two daily meals and two daily exercise periods. There were no significant differences in total food intake and total wheel counts, but feeding before exercise in the morning groups (F-Ex/F-Ex and F-Ex/Ex-F) increased the morning wheel counts. These results suggest that habitual exercise after feeding in the morning and evening is more effective for preventing HFD-induced weight gain. We also determined whether there were any correlations between food intake, wheel rotation, visceral fat volume and skeletal muscle volumes. We found positive associations between gastrocnemius muscle volumes and morning wheel counts, as well as negative associations between morning food intake volumes/body weight and morning wheel counts. These results suggest that morning exercise-induced increase of muscle volume may refer to anti-obesity. Evening exercise is negatively associated with fat volume increases, suggesting that this practice may counteract fat deposition. Our multifactorial analysis revealed that morning food intake helps to increase exercise, and that evening exercise reduced fat volumes. Thus, exercise in the morning or evening is important for preventing the onset of obesity.

    Original languageEnglish
    Pages (from-to)677-686
    Number of pages10
    JournalChronobiology International
    Volume32
    Issue number5
    DOIs
    Publication statusPublished - 2015 Jun 1

    Fingerprint

    High Fat Diet
    Running
    Meals
    Appointments and Schedules
    Obesity
    Eating
    Intra-Abdominal Fat
    Fats
    Body Weight
    Weight Gain
    Skeletal Muscle
    Muscles

    Keywords

    • Circadian rhythm
    • Exercise
    • Meal and exercise timing
    • Obesity

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

    Cite this

    Eating meals before wheel-running exercise attenuate high fat diet-driven obesity in mice under two meals per day schedule. / Sasaki, Hiroyuki; Hattori, Yuta; Ikeda, Yuko; Kamagata, Mayo; Shibata, Shigenobu.

    In: Chronobiology International, Vol. 32, No. 5, 01.06.2015, p. 677-686.

    Research output: Contribution to journalArticle

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