Effect of 2-deoxy-d-glucose on the induction of tyrosinase in Coprinus macrorhizus

Hiroshi Nyunoya; Tatsuno Ishikawa

doi:10.2323/jgam.26.229

Effect of 2-deoxy-d-glucose on the induction of tyrosinase in Coprinus macrorhizus

Hiroshi Nyunoya, Tatsuno Ishikawa

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5 Citations (Scopus)

Abstract

The addition of 2-deoxy-d-glucose and related glucose analogues to the cultures of Coprinus macrorhizus resulted in the induction of tyrosinase production and inhibition of fruiting body formation. The induction was inhibited by cycloheximide or high concentrations of glucose. Electrophoretic analyses revealed that tyrosinase, peroxidase, and tyrosinase inhibitors were present in crude mycelial extracts and that the production of an unusual tyrosinase isozyme was responsible for the enzyme induction.

Original language	English
Pages (from-to)	229-238
Number of pages	10
Journal	The Journal of General and Applied Microbiology
Volume	26
Issue number	3
DOIs	https://doi.org/10.2323/jgam.26.229
Publication status	Published - 1980
Externally published	Yes

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ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology

Cite this

Nyunoya, H., & Ishikawa, T. (1980). Effect of 2-deoxy-d-glucose on the induction of tyrosinase in Coprinus macrorhizus. The Journal of General and Applied Microbiology, 26(3), 229-238. https://doi.org/10.2323/jgam.26.229

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AB - The addition of 2-deoxy-d-glucose and related glucose analogues to the cultures of Coprinus macrorhizus resulted in the induction of tyrosinase production and inhibition of fruiting body formation. The induction was inhibited by cycloheximide or high concentrations of glucose. Electrophoretic analyses revealed that tyrosinase, peroxidase, and tyrosinase inhibitors were present in crude mycelial extracts and that the production of an unusual tyrosinase isozyme was responsible for the enzyme induction.

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10.2323/jgam.26.229