Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man

Linda M. Ueno, M. Miyachi, T. Matsui, K. Takahashi, K. Yamazaki, K. Hayashi, S. Onodera, T. Moritani

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

To examine the possible age-related blood pressure (BP) deregulation in response to central hypervolemia, we measured spontaneous baroreflex sensitivity (SBRS), carotid arterial compliance (CC), and R-R interval coefficient of variation (RRICV) during basal and thermoneutral resting head-out-of-water immersion (HOWI) in 7 young (YG = 24.0 ± 0.8 years) and 6 middle-aged/older (OL = 59.3 ± 1.3 years) healthy men. Compared with basal conditions (YG = 19.6 ± 4.0 vs OL = 6.1 ± 1.5 ms/mmHg, P < 0.05), SBRS remained higher in YG than OL during rest HOWI (YG = 23.6 ± 6.6 vs OL = 9.3 ± 2.1 ms /mmHg, P < 0.05). The RRICV was significantly different between groups (YG = 6.5 ± 1.4 vs OL = 2.8 ± 0.4%, P < 0.05) under HOWI. The OL group had no increase in CC, but a significant increase in systolic BP (basal = 115.3 ± 4.4 vs water = 129.3 ± 5.3 mmHg, P < 0.05) under HOWI. In contrast, the YG group had a significant increase in CC (basal = 0.16 ± 0.01 vs water = 0.17 ± 0.02 mm2/mmHg, P < 0.05) with no changes in systolic BP. SBRS was positively related to CC (r = 0.58, P < 0.05 for basal vs r = 0.62, P < 0.05 for water). Our data suggest that age-related vagal dysfunction and reduced CC may be associated with SBRS differences between YG and OL groups, and with BP elevation during HOWI in healthy older men.

Original languageEnglish
Pages (from-to)629-637
Number of pages9
JournalBrazilian Journal of Medical and Biological Research
Volume38
Issue number4
DOIs
Publication statusPublished - 2005 Apr
Externally publishedYes

Keywords

  • Aging
  • Baroreflex sensitivity
  • Carotid compliance
  • Hypertension
  • Vascular stiffness
  • Water immersion

ASJC Scopus subject areas

  • Biophysics
  • Neuroscience(all)
  • Biochemistry
  • Physiology
  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Cell Biology

Fingerprint Dive into the research topics of 'Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man'. Together they form a unique fingerprint.

Cite this