Effect of alpha-helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome

Jun Tayama, Y. Sagami, Y. Shimada, M. Hongo, S. Fukudo

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Patients with irritable bowel syndrome (IBS) may have a higher tone of corticotropin-releasing hormone (CRH) in the brain. We tested our hypothesis that peripheral administration of CRH antagonist, α-helical CRH 9-41 (αhCRH), improves decreased alpha power spectra and increased beta power spectra of electroencephalogram (EEG) in IBS patients. A barostat bag was inserted to the descending colon of 10 normal controls and 10 IBS patients. The EEG power spectra and topography were measured during baseline period and colonic distention period with the administration of saline followed by the administration of 10 μg kg -1 of αhCRH. IBS patients showed a significantly lower alpha power percentage and a higher beta power percentage than normal controls during baseline. Colonic distention induced a decrease in the alpha power percentage and an increase in the beta power percentage in both groups without difference between groups. After the administration of αhCRH, changes in the EEG power spectra in response to colonic distention were blunted and the differences in the EEG power spectra between IBS patients and controls vanished. Peripheral administration of αhCRH almost normalized EEG activities in IBS patients. Our data strongly suggest that CRH plays an important role in IBS.

Original languageEnglish
Pages (from-to)471-483
Number of pages13
JournalNeurogastroenterology and Motility
Volume19
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1
Externally publishedYes

Fingerprint

Irritable Bowel Syndrome
Electroencephalography
Corticotropin-Releasing Hormone
Descending Colon
Hormone Antagonists
alpha helical corticotropin-releasing hormone
corticotropin releasing hormone (9-41)
Brain

Keywords

  • Brain gut interactions
  • Corticotropin-releasing hormone
  • CRH antagonist
  • Electroencephalogram
  • Irritable bowel syndrome
  • Visceral perception

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Effect of alpha-helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome. / Tayama, Jun; Sagami, Y.; Shimada, Y.; Hongo, M.; Fukudo, S.

In: Neurogastroenterology and Motility, Vol. 19, No. 6, 01.06.2007, p. 471-483.

Research output: Contribution to journalArticle

Tayama, Jun ; Sagami, Y. ; Shimada, Y. ; Hongo, M. ; Fukudo, S. / Effect of alpha-helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome. In: Neurogastroenterology and Motility. 2007 ; Vol. 19, No. 6. pp. 471-483.
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