Effect of amino acids and monoamines on the neuronal activity of suprachiasmatic nucleus in hypothalamic slice preparations

Shigenobu Shibata, S. Y. Liou, S. Ueki

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Influences of amino acids and monamines on the single unit discharges of the suprachiasmatic nucleus (SCN) were investigated using hypothalamic slice preparations. Iontophoretic application of GABA inhibited 90% and taurine inhibited 40% of SCN neurons, whille glycine inhibited only 4%. L-glutamate excited about 50% of the neurons. Serotonin, noradrenaline and dopamine inhibited 30, 22 and 26% of the SCN neurons, respectively. Amino acid effects were observed equally in both the ventrolateral part of the SCN and the remaining part of it, while monoamine effects were observed preferentially in the ventrolateral part of the SCN where the optic fibers and serotonin nerves terminated. These results suggest that amino acids and monoamines modulate the neuronal activity of the SCN through their direct effects.

Original languageEnglish
Pages (from-to)1225-1231
Number of pages7
JournalJapanese Journal of Pharmacology
Volume33
Issue number6
Publication statusPublished - 1983
Externally publishedYes

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Suprachiasmatic Nucleus
Amino Acids
Neurons
Serotonin
Taurine
Nerve Fibers
Glycine
gamma-Aminobutyric Acid
Glutamic Acid
Dopamine
Norepinephrine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of amino acids and monoamines on the neuronal activity of suprachiasmatic nucleus in hypothalamic slice preparations. / Shibata, Shigenobu; Liou, S. Y.; Ueki, S.

In: Japanese Journal of Pharmacology, Vol. 33, No. 6, 1983, p. 1225-1231.

Research output: Contribution to journalArticle

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