Effect of attention bias modification on brain function and anxiety in patients with irritable bowel syndrome

A preliminary electroencephalogram and psycho-behavioral study

Jun Tayama, T. Saigo, S. Ogawa, A. Takeoka, T. Hamaguchi, M. Hayashida, S. Fukudo, S. Shirabe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Gastrointestinal symptoms of irritable bowel syndrome (IBS) show a reciprocal relationship with anxiety. In this intervention-based study, we investigated the utility of attention bias modification (ABM) therapy in patients with IBS. We hypothesized that IBS-related electroencephalographic abnormalities would be normalized after ABM therapy. Methods: Seventeen patients with IBS and 13 healthy subjects completed five ABM intervention sessions over a 2-month period. Each session included 128 ABM trials, resulting in a total of 640 trials across the intervention period. For each trial, subjects viewed a pair of facial expression images and were instructed to indicate the position of the neutral face as quickly and accurately as possible by pressing one of two buttons on a button box. Electroencephalography data (alpha and beta power percentages) were collected during the 1st and 5th sessions. Key Results: Generalized estimating equations of relative alpha power revealed a significant effect of period was identified at O2 (P=.036). Paired t tests revealed that ABM significantly increased relative alpha power at O2 in patients with IBS. Generalized estimating equation of relative beta power revealed a significant effect of the group × period interaction was identified at Pz (P=.035). Paired t tests revealed that ABM significantly decreased relative beta power at Pz in patients with IBS. Conclusions & Inferences: Attention bias modification may normalize brain function related to attention and anxiety in patients with IBS.

Original languageEnglish
Article numbere13131
JournalNeurogastroenterology and Motility
Volume29
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1
Externally publishedYes

Fingerprint

Irritable Bowel Syndrome
Electroencephalography
Anxiety
Brain
Facial Expression
Healthy Volunteers
Power (Psychology)
Therapeutics

Keywords

  • anxiety
  • attention bias modification
  • electroencephalography
  • irritable bowel syndrome
  • reaction time

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Effect of attention bias modification on brain function and anxiety in patients with irritable bowel syndrome : A preliminary electroencephalogram and psycho-behavioral study. / Tayama, Jun; Saigo, T.; Ogawa, S.; Takeoka, A.; Hamaguchi, T.; Hayashida, M.; Fukudo, S.; Shirabe, S.

In: Neurogastroenterology and Motility, Vol. 29, No. 12, e13131, 01.12.2017.

Research output: Contribution to journalArticle

Tayama, Jun ; Saigo, T. ; Ogawa, S. ; Takeoka, A. ; Hamaguchi, T. ; Hayashida, M. ; Fukudo, S. ; Shirabe, S. / Effect of attention bias modification on brain function and anxiety in patients with irritable bowel syndrome : A preliminary electroencephalogram and psycho-behavioral study. In: Neurogastroenterology and Motility. 2017 ; Vol. 29, No. 12.
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