Effect of attention bias modification on event-related potentials in patients with irritable bowel syndrome

A preliminary brain function and psycho-behavioral study

Jun Tayama, T. Saigo, S. Ogawa, A. Takeoka, T. Hamaguchi, K. Inoue, H. Okamura, J. Yajima, K. Matsudaira, S. Fukudo, S. Shirabe

Research output: Contribution to journalArticle

Abstract

Background: Attention bias modification normalizes electroencephalographic abnormalities in alpha and beta power percentages related to attention in patients with irritable bowel syndrome (IBS). Yet, it is unknown whether ABM contributes to the normalization of event-related potentials (ERP) in these patients. We hypothesized that ERP related to attention deficit would be normalized after ABM implementation in individuals with IBS. Methods: Thirteen patients with IBS and 10 control subjects completed a 2-month intervention that included five ABM sessions. Each session included 128 trials, resulting in a total of 640 trials during the study period. Event-related potentials were measured at the first and fifth sessions. As per the international 10-20 system for electroencephalographic electrode placement, right parietal P4 was evaluated to measure the attention component of facial expression processing. Key Results: A group comparison of P100 latency at P4 revealed that latencies were significantly different between groups in session 1 (IBS vs control, 108 ± 8 vs 97 ± 14; t = −2.51, P =.0203). This difference was absent in session 5 (94 ± 11 vs 93 ± 11, respectively; t = −0.397, P =.6954, r =.09), indicating an effect of ABM in the IBS group. Conclusions and inferences: Attention bias modification may have clinical utility for normalizing brain function and specifically attentional abnormalities in patients with IBS.

Original languageEnglish
Article numbere13402
JournalNeurogastroenterology and Motility
Volume30
Issue number10
DOIs
Publication statusPublished - 2018 Oct 1
Externally publishedYes

Fingerprint

Irritable Bowel Syndrome
Evoked Potentials
Brain
Facial Expression
Electrodes

Keywords

  • attentional bias
  • electroencephalography
  • evoked potentials
  • irritable bowel syndrome

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Effect of attention bias modification on event-related potentials in patients with irritable bowel syndrome : A preliminary brain function and psycho-behavioral study. / Tayama, Jun; Saigo, T.; Ogawa, S.; Takeoka, A.; Hamaguchi, T.; Inoue, K.; Okamura, H.; Yajima, J.; Matsudaira, K.; Fukudo, S.; Shirabe, S.

In: Neurogastroenterology and Motility, Vol. 30, No. 10, e13402, 01.10.2018.

Research output: Contribution to journalArticle

Tayama, J, Saigo, T, Ogawa, S, Takeoka, A, Hamaguchi, T, Inoue, K, Okamura, H, Yajima, J, Matsudaira, K, Fukudo, S & Shirabe, S 2018, 'Effect of attention bias modification on event-related potentials in patients with irritable bowel syndrome: A preliminary brain function and psycho-behavioral study', Neurogastroenterology and Motility, vol. 30, no. 10, e13402. https://doi.org/10.1111/nmo.13402
Tayama, Jun ; Saigo, T. ; Ogawa, S. ; Takeoka, A. ; Hamaguchi, T. ; Inoue, K. ; Okamura, H. ; Yajima, J. ; Matsudaira, K. ; Fukudo, S. ; Shirabe, S. / Effect of attention bias modification on event-related potentials in patients with irritable bowel syndrome : A preliminary brain function and psycho-behavioral study. In: Neurogastroenterology and Motility. 2018 ; Vol. 30, No. 10.
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