Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms

Nagisa Sugaya, Shuhei Izawa, Namiko Ogawa, Kentaro Shirotsuki, Hitomi Kobayashi, Kosuke C. Yamada, Hideki Tsumura, Shinobu Nomura, Hironori Shimada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: The hypothalamic-pituitary-adrenal axis is known to be related to abdominal symptoms, and the relationship between abdominal pain and cortisol secretory patterns has been previously investigated using a cross-sectional approach. Here, we investigated the effect of day-to-day variations in salivary cortisol and dehydroepiandrosterone-sulfate levels on abdominal symptoms in healthy individuals.Methods: Eleven college students (4 males and 7 females) participated in this study. The participants were asked to collect their saliva immediately after awakening and before bedtime for eight consecutive days. They also completed a questionnaire about abdominal symptoms before bedtime. The linear mixed model was applied to analyze the effects of the day-by-day variability or the 8-day average adrenal hormone level (at awakening, before bedtime, slope from awakening to bedtime) on abdominal symptoms.Results: The day-to-day variability of cortisol levels before bedtime was negatively related with loose stool, while the day-to-day variability of the cortisol slope was positively correlated with loose stool. A low 8-day average dehydroepiandrosterone-sulfate level at awakening was positively related with frequent bowel movements, loose stool, and long bouts of severe abdominal pain. Likewise, a low 8-day average dehydroepiandrosterone-sulfate slope was positively related with long bouts of abdominal pain.Conclusions: Low cortisol levels before bedtime and a steeper diurnal cortisol slope during the day may be related to bouts of diarrhea during the day.

Original languageEnglish
Article number2
JournalBioPsychoSocial Medicine
Volume4
DOIs
Publication statusPublished - 2010 Mar 18

ASJC Scopus subject areas

  • Social Psychology
  • Psychology(all)
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Sugaya, N., Izawa, S., Ogawa, N., Shirotsuki, K., Kobayashi, H., Yamada, K. C., Tsumura, H., Nomura, S., & Shimada, H. (2010). Effect of day-to-day variations in adrenal cortex hormone levels on abdominal symptoms. BioPsychoSocial Medicine, 4, [2]. https://doi.org/10.1186/1751-0759-4-2