Effect of electrochemically structured titanium alloys on cell morphology

S. Roy, Qi Bai Wu, S. Nouraei, S. Ngalim, M. Birch, A. McCaskie, H. Zhang, T. Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ti alloys are commonly used as dental and orthopaedic implants. It has been shown that surface topography can influence cell genesis, behaviour and growth. In this work we have electropolished and micro-patterned Ti-6Al-4V alloy to study the effect of surface topography on cell morphology. Electroetching was carried out in a flat cell under galvanostatic polarisation of 5.0 V and 9.0 V vs. SCE, using a 3.0 M H2SO4 - methanol electrolyte. Electropolishing conditions were achieved when the overpotential was 9.0 V. Micropatterning of Ti alloy substrates was carried out at the same potentials by etching through mask; a methanol stable SU-8 photoresist was used for this purpose. Human mesenchymal stem cells were seeded and grown on these substrates. It was found that surface nano and micro scale topography influenced cell numbers and morphology, respectively.

Original languageEnglish
Title of host publicationECS Transactions - Biological Nanostructures, Materials, and Applications - 214th ECS Meeting
Pages17-25
Number of pages9
Edition38
DOIs
Publication statusPublished - 2009 Nov 23
EventBiological Nanostructures, Materials, and Applications - 214th ECS Meeting - Honolulu, HI, United States
Duration: 2008 Oct 122008 Oct 17

Publication series

NameECS Transactions
Number38
Volume16
ISSN (Print)1938-5862
ISSN (Electronic)1938-6737

Conference

ConferenceBiological Nanostructures, Materials, and Applications - 214th ECS Meeting
CountryUnited States
CityHonolulu, HI
Period08/10/1208/10/17

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Roy, S., Wu, Q. B., Nouraei, S., Ngalim, S., Birch, M., McCaskie, A., Zhang, H., & Osaka, T. (2009). Effect of electrochemically structured titanium alloys on cell morphology. In ECS Transactions - Biological Nanostructures, Materials, and Applications - 214th ECS Meeting (38 ed., pp. 17-25). (ECS Transactions; Vol. 16, No. 38). https://doi.org/10.1149/1.3103806