Effect of exercise training on aortic collagen content in spontaneously hypertensive rats (SHR)

Mitsuru Higuchi, Isao Hashimoto, Kikue Yamakawa

Research output: Contribution to journalArticle

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Abstract

We investigated the effects of exercise training on the amount of aortic collagen and systolic blood pressure in spontaneously hypertensive rats (SHR). Ten-week old SHR were trained either by forced treadmill running (26.8 m·min-1 h·day-1, five times a week, 0% incline) or by voluntary running in revolving wheels (7,800 m·day-1 at peak) for 8 weeks. Succinate dehydrogenase (SDH) activity measured as a marker of an endurance training effect was 13% higher (P<0.01) in the soleus of forced-exercised animals than in that of sedentary ones. (6.56±0.17 Μmol·g-1·min-1; mean ± SEM), whereas SDH activity in that of voluntarily-exercised group was found to be at the same level as in sedentary animals. The systolic blood pressure after training increased by 26.4 in sedentary, 21.1 in voluntarily-exercised, and 33.9 mm Hg in forced-exercised rats, when compared with the value of each group at the beginning of the training programm. A significant difference was observed in the increment of blood pressure only between the voluntarily- and forced-exercised groups (P<0.05). The amount of aortic collagen in voluntarily-trained rats (96.5±2.0 mg·g tissue-1, 39.8±0.7 mg·100 mg protein-1) was significantly less than that in forced-trained rats (P<0.05). These results suggest that voluntary, mild exercise training may be more effective in the reduction of collagen accumulation in the aorta associated with the suppression of blood pressure increase than forced, vigorous exercise training in SHR.

Original languageEnglish
Pages (from-to)330-333
Number of pages4
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Volume53
Issue number4
DOIs
Publication statusPublished - 1985 Feb
Externally publishedYes

Fingerprint

Inbred SHR Rats
Collagen
Exercise
Blood Pressure
Succinate Dehydrogenase
Running
Aorta
Proteins

Keywords

  • Aortic collagen
  • Blood pressure
  • Exercise
  • SHR rats

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physiology

Cite this

Effect of exercise training on aortic collagen content in spontaneously hypertensive rats (SHR). / Higuchi, Mitsuru; Hashimoto, Isao; Yamakawa, Kikue.

In: European Journal of Applied Physiology and Occupational Physiology, Vol. 53, No. 4, 02.1985, p. 330-333.

Research output: Contribution to journalArticle

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