Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line

Sumio Noguchi, Yoshinobu Kubota, Taro Shuin, Etsuro Ito, Hiroko Inoue, Tohru Yoshioka

    Research output: Contribution to journalArticle

    Abstract

    Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.

    Original languageEnglish
    Pages (from-to)644-650
    Number of pages7
    JournalBiochemical and Biophysical Research Communications
    Volume182
    Issue number2
    DOIs
    Publication statusPublished - 1992 Jan 31

    Fingerprint

    myc Genes
    Kidney Neoplasms
    Phosphatidylinositols
    Genes
    Cells
    Liposomes
    Cell Line
    Soybeans
    Protein Kinase C
    Culture Media
    Neoplasms

    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

    Cite this

    Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line. / Noguchi, Sumio; Kubota, Yoshinobu; Shuin, Taro; Ito, Etsuro; Inoue, Hiroko; Yoshioka, Tohru.

    In: Biochemical and Biophysical Research Communications, Vol. 182, No. 2, 31.01.1992, p. 644-650.

    Research output: Contribution to journalArticle

    Noguchi, Sumio ; Kubota, Yoshinobu ; Shuin, Taro ; Ito, Etsuro ; Inoue, Hiroko ; Yoshioka, Tohru. / Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line. In: Biochemical and Biophysical Research Communications. 1992 ; Vol. 182, No. 2. pp. 644-650.
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