Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line

Sumio Noguchi, Yoshinobu Kubota, Taro Shuin, Etsuro Ito, Hiroko Inoue, Tohru Yoshioka

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    Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.

    Original languageEnglish
    Pages (from-to)644-650
    Number of pages7
    JournalBiochemical and Biophysical Research Communications
    Issue number2
    Publication statusPublished - 1992 Jan 31


    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Molecular Biology

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