Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line

Sumio Noguchi, Yoshinobu Kubota, Taro Shuin, Etsuro Ito, Hiroko Inoue, Tohru Yoshioka

Research output: Contribution to journalArticle

Abstract

Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.

Original languageEnglish
Pages (from-to)644-650
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume182
Issue number2
DOIs
Publication statusPublished - 1992 Jan 31

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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