Effect of fluctuation in step size on actin-myosin sliding motion

Yuki Kagawa

    Research output: Contribution to journalArticle

    Abstract

    It is possible that the step size, or power stroke, of a skeletal muscle myosin is not constant; rather, it fluctuates for each force generation. The estimated widths of the fluctuation are as large as the estimated values of the step size. Although such non-negligible fluctuation is presumed to affect the sliding motion, these effects remain unclear. We examined a system driven by a single myosin molecule sliding along an actin filament to reveal its basic effects. First, we calculated the sliding velocity of the system for each fluctuation width and found that the mean velocity increased with the fluctuation width. We also found that the estimated fluctuation widths satisfied the conditions for maximizing the sliding velocity. Next, we examined the sliding motion along a heterogeneous filament, on which binding sites for myosins were distributed randomly. We found that the loss in sliding velocity that was attributable to heterogeneity of the filament became small when fluctuation in the step size existed. This finding implied that the fluctuation stabilized velocity sliding along possible heterogeneous filaments. These benefits of fluctuation in step size might be used in biological systems, such as a muscle system, and are applicable to fabricated micromachines.

    Original languageEnglish
    Article number011923
    JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
    Volume75
    Issue number1
    DOIs
    Publication statusPublished - 2007

    Fingerprint

    myosins
    Myosin
    Actin
    sliding
    Fluctuations
    Motion
    Filament
    filaments
    skeletal muscle
    Skeletal muscle
    muscles
    strokes
    Stroke
    Biological Systems
    Muscle
    Molecules

    ASJC Scopus subject areas

    • Physics and Astronomy(all)
    • Condensed Matter Physics
    • Statistical and Nonlinear Physics
    • Mathematical Physics

    Cite this

    Effect of fluctuation in step size on actin-myosin sliding motion. / Kagawa, Yuki.

    In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 75, No. 1, 011923, 2007.

    Research output: Contribution to journalArticle

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