Effect of immunoglobulins and IgG-fragments on the human erythrocyte aggregation, studied by a rheoscope combined with image analyzer

K. Imaizumi, T. Shiga

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Using a rheoscope, combined with a TV image analyzer and a computer, the effects of immunoglobulins and IgG-fragments on the process of human erythrocyte aggregation were determined. The immunoglobulins accelerated the aggregation; the effect increased with their molecular weight, i.e., IgG ≃ γ-globulin < IgA < IgM. An empirical relationship, expressing the dependence on the immunoglobulin concentrations, was proposed. F(ab')2-fragment accelerated the aggregation, more effectively than IgG, while Fab- and Fc-fragments did not. Therefore, two Fab-portions are presumably needed to form the aggregates, and the flexibility between two Fab-portions may be important. A case of multiple myeloma showed an increased aggregation, due to increased myeloma protein.

Original languageEnglish
Pages (from-to)569-577
Number of pages9
JournalBiorheology
Volume20
Issue number5
Publication statusPublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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