Effect of megestrol acetate or melengestrol acetate on preneoplastic and neoplastic mammary growth in mice

H. Nagasawa; N. Sakagami; R. Ohbayashi; K. Yamamoto; V. Petrow

Effect of megestrol acetate or melengestrol acetate on preneoplastic and neoplastic mammary growth in mice

H. Nagasawa, N. Sakagami, R. Ohbayashi, K. Yamamoto, V. Petrow

Research output: Contribution to journal › Article › peer-review

Abstract

Pellets of megestrol acetate and melengestrol acetate were implanted subcutaneously every one and two months, respectively, into 3-5 month old SHN virgin mice. Spontaneous mammary tumourigenesis was significantly enhanced by both steroids. The formation of preneoplastic mammary hyperplastic alveolar nodules (HAN) was, in contrast, inhibited by both progestins. As these results closely resemble the effects of progesterone and of medroxyprogesterone acetate on the development of mammary tumours both in the SHN mouse and in the woman, it seems likely that this animal model may prove valuable for the study of human breast cancer that is no longer responsive to progestins.

Original language	English
Pages (from-to)	1399-1403
Number of pages	5
Journal	Anticancer Research
Volume	8
Issue number	6
Publication status	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Effect of megestrol acetate or melengestrol acetate on preneoplastic and neoplastic mammary growth in mice",

abstract = "Pellets of megestrol acetate and melengestrol acetate were implanted subcutaneously every one and two months, respectively, into 3-5 month old SHN virgin mice. Spontaneous mammary tumourigenesis was significantly enhanced by both steroids. The formation of preneoplastic mammary hyperplastic alveolar nodules (HAN) was, in contrast, inhibited by both progestins. As these results closely resemble the effects of progesterone and of medroxyprogesterone acetate on the development of mammary tumours both in the SHN mouse and in the woman, it seems likely that this animal model may prove valuable for the study of human breast cancer that is no longer responsive to progestins.",

author = "H. Nagasawa and N. Sakagami and R. Ohbayashi and K. Yamamoto and V. Petrow",

year = "1988",

language = "English",

volume = "8",

pages = "1399--1403",

journal = "Anticancer Research",

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T1 - Effect of megestrol acetate or melengestrol acetate on preneoplastic and neoplastic mammary growth in mice

AU - Nagasawa, H.

AU - Sakagami, N.

AU - Ohbayashi, R.

AU - Yamamoto, K.

AU - Petrow, V.

PY - 1988

Y1 - 1988

N2 - Pellets of megestrol acetate and melengestrol acetate were implanted subcutaneously every one and two months, respectively, into 3-5 month old SHN virgin mice. Spontaneous mammary tumourigenesis was significantly enhanced by both steroids. The formation of preneoplastic mammary hyperplastic alveolar nodules (HAN) was, in contrast, inhibited by both progestins. As these results closely resemble the effects of progesterone and of medroxyprogesterone acetate on the development of mammary tumours both in the SHN mouse and in the woman, it seems likely that this animal model may prove valuable for the study of human breast cancer that is no longer responsive to progestins.

AB - Pellets of megestrol acetate and melengestrol acetate were implanted subcutaneously every one and two months, respectively, into 3-5 month old SHN virgin mice. Spontaneous mammary tumourigenesis was significantly enhanced by both steroids. The formation of preneoplastic mammary hyperplastic alveolar nodules (HAN) was, in contrast, inhibited by both progestins. As these results closely resemble the effects of progesterone and of medroxyprogesterone acetate on the development of mammary tumours both in the SHN mouse and in the woman, it seems likely that this animal model may prove valuable for the study of human breast cancer that is no longer responsive to progestins.

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JO - Anticancer Research

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SN - 0250-7005

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