Effect of midbrain stimulations on thermoregulatory vasomotor responses in rats

Yi Hong Zhang, Takayoshi Hosono, Motoko Yanase-Fujiwara, Xiao Ming Chen, Kazuyuki Kanosue

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

1. Efferent projections eliciting vasodilatation when the preoptic area is warmed were investigated by monitoring tail vasomotor responses of ketamine-anaesthetized rats when brain areas were stimulated electrically (0.2 mA, 200 μs, 30 Hz) or with the excitatory amino acid D,L-homocysteic acid (1 mM, 0.3 μl). 2. Both stimulations elicited vasodilatation when applied within a region extending from the most caudal part of the lateral hypothalamus to the ventrolateral periaqueductal grey matter (PAG) and the reticular formation ventrolateral to the PAG. 3. Vasodilatation elicited by preoptic warming was suppressed when either stimulation was applied within the rostral part of the ventral tegmental area (VTA). 4. Sustained vasodilatation was elicited by knife cuts caudal to the VTA, and vasodilatation elicited by preoptic warming was suppressed by cuts either rostral to the VTA or in the region including the PAG and the reticular formation ventrolateral to it. 5. These results, together with the results of earlier physiological and histological studies, suggest that warm-sensitive neurones in the preoptic area send excitatory signals to vasodilatative neurones in the caudal part of the lateral hypothalamus, ventrolateral PAG and reticular formation, and send inhibitory signals to vasoconstrictive neurones in the rostral part of the VTA.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalJournal of Physiology
Volume503
Issue number1
DOIs
Publication statusPublished - 1997 Aug 15
Externally publishedYes

Fingerprint

Mesencephalon
Periaqueductal Gray
Ventral Tegmental Area
Vasodilation
Reticular Formation
Lateral Hypothalamic Area
Preoptic Area
Neurons
Excitatory Amino Acids
Ketamine
Tail
Brain

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of midbrain stimulations on thermoregulatory vasomotor responses in rats. / Zhang, Yi Hong; Hosono, Takayoshi; Yanase-Fujiwara, Motoko; Chen, Xiao Ming; Kanosue, Kazuyuki.

In: Journal of Physiology, Vol. 503, No. 1, 15.08.1997, p. 177-186.

Research output: Contribution to journalArticle

Zhang, Yi Hong ; Hosono, Takayoshi ; Yanase-Fujiwara, Motoko ; Chen, Xiao Ming ; Kanosue, Kazuyuki. / Effect of midbrain stimulations on thermoregulatory vasomotor responses in rats. In: Journal of Physiology. 1997 ; Vol. 503, No. 1. pp. 177-186.
@article{9d33c11f67d0488a9850c2c0093b3782,
title = "Effect of midbrain stimulations on thermoregulatory vasomotor responses in rats",
abstract = "1. Efferent projections eliciting vasodilatation when the preoptic area is warmed were investigated by monitoring tail vasomotor responses of ketamine-anaesthetized rats when brain areas were stimulated electrically (0.2 mA, 200 μs, 30 Hz) or with the excitatory amino acid D,L-homocysteic acid (1 mM, 0.3 μl). 2. Both stimulations elicited vasodilatation when applied within a region extending from the most caudal part of the lateral hypothalamus to the ventrolateral periaqueductal grey matter (PAG) and the reticular formation ventrolateral to the PAG. 3. Vasodilatation elicited by preoptic warming was suppressed when either stimulation was applied within the rostral part of the ventral tegmental area (VTA). 4. Sustained vasodilatation was elicited by knife cuts caudal to the VTA, and vasodilatation elicited by preoptic warming was suppressed by cuts either rostral to the VTA or in the region including the PAG and the reticular formation ventrolateral to it. 5. These results, together with the results of earlier physiological and histological studies, suggest that warm-sensitive neurones in the preoptic area send excitatory signals to vasodilatative neurones in the caudal part of the lateral hypothalamus, ventrolateral PAG and reticular formation, and send inhibitory signals to vasoconstrictive neurones in the rostral part of the VTA.",
author = "Zhang, {Yi Hong} and Takayoshi Hosono and Motoko Yanase-Fujiwara and Chen, {Xiao Ming} and Kazuyuki Kanosue",
year = "1997",
month = "8",
day = "15",
doi = "10.1111/j.1469-7793.1997.177bi.x",
language = "English",
volume = "503",
pages = "177--186",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Effect of midbrain stimulations on thermoregulatory vasomotor responses in rats

AU - Zhang, Yi Hong

AU - Hosono, Takayoshi

AU - Yanase-Fujiwara, Motoko

AU - Chen, Xiao Ming

AU - Kanosue, Kazuyuki

PY - 1997/8/15

Y1 - 1997/8/15

N2 - 1. Efferent projections eliciting vasodilatation when the preoptic area is warmed were investigated by monitoring tail vasomotor responses of ketamine-anaesthetized rats when brain areas were stimulated electrically (0.2 mA, 200 μs, 30 Hz) or with the excitatory amino acid D,L-homocysteic acid (1 mM, 0.3 μl). 2. Both stimulations elicited vasodilatation when applied within a region extending from the most caudal part of the lateral hypothalamus to the ventrolateral periaqueductal grey matter (PAG) and the reticular formation ventrolateral to the PAG. 3. Vasodilatation elicited by preoptic warming was suppressed when either stimulation was applied within the rostral part of the ventral tegmental area (VTA). 4. Sustained vasodilatation was elicited by knife cuts caudal to the VTA, and vasodilatation elicited by preoptic warming was suppressed by cuts either rostral to the VTA or in the region including the PAG and the reticular formation ventrolateral to it. 5. These results, together with the results of earlier physiological and histological studies, suggest that warm-sensitive neurones in the preoptic area send excitatory signals to vasodilatative neurones in the caudal part of the lateral hypothalamus, ventrolateral PAG and reticular formation, and send inhibitory signals to vasoconstrictive neurones in the rostral part of the VTA.

AB - 1. Efferent projections eliciting vasodilatation when the preoptic area is warmed were investigated by monitoring tail vasomotor responses of ketamine-anaesthetized rats when brain areas were stimulated electrically (0.2 mA, 200 μs, 30 Hz) or with the excitatory amino acid D,L-homocysteic acid (1 mM, 0.3 μl). 2. Both stimulations elicited vasodilatation when applied within a region extending from the most caudal part of the lateral hypothalamus to the ventrolateral periaqueductal grey matter (PAG) and the reticular formation ventrolateral to the PAG. 3. Vasodilatation elicited by preoptic warming was suppressed when either stimulation was applied within the rostral part of the ventral tegmental area (VTA). 4. Sustained vasodilatation was elicited by knife cuts caudal to the VTA, and vasodilatation elicited by preoptic warming was suppressed by cuts either rostral to the VTA or in the region including the PAG and the reticular formation ventrolateral to it. 5. These results, together with the results of earlier physiological and histological studies, suggest that warm-sensitive neurones in the preoptic area send excitatory signals to vasodilatative neurones in the caudal part of the lateral hypothalamus, ventrolateral PAG and reticular formation, and send inhibitory signals to vasoconstrictive neurones in the rostral part of the VTA.

UR - http://www.scopus.com/inward/record.url?scp=0030756429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030756429&partnerID=8YFLogxK

U2 - 10.1111/j.1469-7793.1997.177bi.x

DO - 10.1111/j.1469-7793.1997.177bi.x

M3 - Article

C2 - 9288685

AN - SCOPUS:0030756429

VL - 503

SP - 177

EP - 186

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

IS - 1

ER -