Effect of multinuclear copper/aluminum complexes in highly asymmetric conjugate addition of trimethylaluminum to acyclic enones

Kohei Endo, Daisuke Hamada, Sayuri Yakeishi, Takanori Shibata

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    Al and friends: Asymmetric conjugate addition of Me3Al to β,β-disubstituted α,β-unsaturated ketones in the presence copper and L1 leads to a highly efficient construction of an all-carbon-substituted chiral quaternary center. This result is the first example of an asymmetric conjugate addition of Me3Al to acyclic enones to give a chiral quaternary carbon center with excellent yield and enantioselectivity under mild reaction conditions.

    Original languageEnglish
    Pages (from-to)606-610
    Number of pages5
    JournalAngewandte Chemie - International Edition
    Volume52
    Issue number2
    DOIs
    Publication statusPublished - 2013 Jan 7

    Fingerprint

    Aluminum
    Copper
    Carbon
    Enantioselectivity
    Ketones

    Keywords

    • aluminum
    • copper
    • homogeneous catalysis
    • natural products
    • synthetic methods

    ASJC Scopus subject areas

    • Chemistry(all)
    • Catalysis

    Cite this

    Effect of multinuclear copper/aluminum complexes in highly asymmetric conjugate addition of trimethylaluminum to acyclic enones. / Endo, Kohei; Hamada, Daisuke; Yakeishi, Sayuri; Shibata, Takanori.

    In: Angewandte Chemie - International Edition, Vol. 52, No. 2, 07.01.2013, p. 606-610.

    Research output: Contribution to journalArticle

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