Al and friends: Asymmetric conjugate addition of Me3Al to β,β-disubstituted α,β-unsaturated ketones in the presence copper and L1 leads to a highly efficient construction of an all-carbon-substituted chiral quaternary center. This result is the first example of an asymmetric conjugate addition of Me3Al to acyclic enones to give a chiral quaternary carbon center with excellent yield and enantioselectivity under mild reaction conditions.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2013 Jan 7|
- homogeneous catalysis
- natural products
- synthetic methods
ASJC Scopus subject areas