Effect of multinuclear copper/aluminum complexes in highly asymmetric conjugate addition of trimethylaluminum to acyclic enones

Kohei Endo, Daisuke Hamada, Sayuri Yakeishi, Takanori Shibata

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Al and friends: Asymmetric conjugate addition of Me3Al to β,β-disubstituted α,β-unsaturated ketones in the presence copper and L1 leads to a highly efficient construction of an all-carbon-substituted chiral quaternary center. This result is the first example of an asymmetric conjugate addition of Me3Al to acyclic enones to give a chiral quaternary carbon center with excellent yield and enantioselectivity under mild reaction conditions.

Original languageEnglish
Pages (from-to)606-610
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number2
DOIs
Publication statusPublished - 2013 Jan 7

Keywords

  • aluminum
  • copper
  • homogeneous catalysis
  • natural products
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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