Effect of phase transition on photosensitized radical polymerization of diene-containing lipids as liposomes

Hiroyuki Ohno, Shinji Takeoka, Hidetaka Iwai, Eishun Tsuchida

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    1,2-Bis(2,4-octadecadienoyl)-sn-glycero-3-phosphorylcholine (DODPC) was polymerized in liposomes by organic free radicals which were generated by photosensitized cleavage of the added azo-type radical initiators such as azobis(isobutyronitrile) (AIBN) or azobis(2-amidinopropane) dihydrochloride (AAPD). Selective polymerization of diene groups on the 1- or 2-acyl chain of DODPC was carried out with water-insoluble AIBN or water-soluble AAPD, respectively, at any temperature, even at temperatures lower than the phase transition temperature (Tc) of the DODPC liposomes. The results of the photosensitized polymerization with water-soluble AAPD clearly reflect the changes in membrane permeability above and below Tc. Applying impermeability of AAPD below Tc, we prepared outer or inner polymerized liposomes. These liposomes possess both stability and fluidity. Initial polymerization rates of photosensitized polymerization with water-insoluble AIBN provided information about the relative microviscosity of the membrane.

    Original languageEnglish
    Pages (from-to)61-66
    Number of pages6
    JournalMacromolecules
    Volume22
    Issue number1
    Publication statusPublished - 1989 Jan

    Fingerprint

    Liposomes
    Free radical polymerization
    Lipids
    Phase transitions
    Polymerization
    Water
    Membranes
    Fluidity
    Free radicals
    Superconducting transition temperature
    Phosphorylcholine
    Temperature
    Free Radicals
    azobis(isobutyronitrile)

    ASJC Scopus subject areas

    • Materials Chemistry

    Cite this

    Effect of phase transition on photosensitized radical polymerization of diene-containing lipids as liposomes. / Ohno, Hiroyuki; Takeoka, Shinji; Iwai, Hidetaka; Tsuchida, Eishun.

    In: Macromolecules, Vol. 22, No. 1, 01.1989, p. 61-66.

    Research output: Contribution to journalArticle

    Ohno, Hiroyuki ; Takeoka, Shinji ; Iwai, Hidetaka ; Tsuchida, Eishun. / Effect of phase transition on photosensitized radical polymerization of diene-containing lipids as liposomes. In: Macromolecules. 1989 ; Vol. 22, No. 1. pp. 61-66.
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