Effect of piceatannol on circadian Per2 expression in vitro and in vivo

Takayuki Yamamoto, Shiho Iwami, Shinya Aoyama, Hiroko Maruki-Uchida, Sadao Mori, Rina Hirooka, Kengo Takahashi, Minoru Morita, Shigenobu Shibata

Research output: Contribution to journalArticle

Abstract

In addition to the development of chrononutrition, food ingredients have been demonstrated to contribute to expression changes in the peripheral clock genes responsible for circadian rhythms. Passion fruit seeds extract (PFSE) contains a high concentration of piceatannol that exhibits many physiological activities; however, whether PFSE and piceatannol affect clock genes is not known with certainty. In this study, we evaluated the effects of PFSE and piceatannol on the rhythm of PER2 using bioluminescence in mPer2 Luc knock-in mice and their embryonic fibroblasts. Piceatannol was demonstrated to advance and delay the phase of PER2::LUC oscillation owing to differences in timing of treatment in vitro. In the in vivo imaging system, oral administration of piceatannol significantly advanced the luminescence rhythm of PER2::LUC in peripheral organs. Furthermore, piceatannol recovered the phase change of PER2::LUC disturbed by high-fat diet intake. These findings indicate that piceatannol affects peripheral clock gene expression and may prevent circadian disturbance.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalJournal of Functional Foods
Volume56
DOIs
Publication statusPublished - 2019 May 1

Fingerprint

passion fruits
fruit extracts
seed extracts
bioluminescence
luminescence
Fruit
Seeds
phase transition
high fat diet
circadian rhythm
oral administration
fibroblasts
oscillation
ingredients
genes
image analysis
gene expression
mice
High Fat Diet
Circadian Rhythm

Keywords

  • Circadian rhythm
  • Passion fruit seed extract
  • Per2
  • Piceatannol

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effect of piceatannol on circadian Per2 expression in vitro and in vivo. / Yamamoto, Takayuki; Iwami, Shiho; Aoyama, Shinya; Maruki-Uchida, Hiroko; Mori, Sadao; Hirooka, Rina; Takahashi, Kengo; Morita, Minoru; Shibata, Shigenobu.

In: Journal of Functional Foods, Vol. 56, 01.05.2019, p. 49-56.

Research output: Contribution to journalArticle

Yamamoto, T, Iwami, S, Aoyama, S, Maruki-Uchida, H, Mori, S, Hirooka, R, Takahashi, K, Morita, M & Shibata, S 2019, 'Effect of piceatannol on circadian Per2 expression in vitro and in vivo', Journal of Functional Foods, vol. 56, pp. 49-56. https://doi.org/10.1016/j.jff.2019.02.042
Yamamoto T, Iwami S, Aoyama S, Maruki-Uchida H, Mori S, Hirooka R et al. Effect of piceatannol on circadian Per2 expression in vitro and in vivo. Journal of Functional Foods. 2019 May 1;56:49-56. https://doi.org/10.1016/j.jff.2019.02.042
Yamamoto, Takayuki ; Iwami, Shiho ; Aoyama, Shinya ; Maruki-Uchida, Hiroko ; Mori, Sadao ; Hirooka, Rina ; Takahashi, Kengo ; Morita, Minoru ; Shibata, Shigenobu. / Effect of piceatannol on circadian Per2 expression in vitro and in vivo. In: Journal of Functional Foods. 2019 ; Vol. 56. pp. 49-56.
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