Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia

Hiromichi Akahori, Kazunori Shibuya, Masako Obuchi, Yoshito Nishizawa, Akio Tsuji, Koji Kabaya, Masaru Kusaka, Hideya Ohashi, Haruhiko Tsumura, Takashi Kato, Hiroshi Miyazaki

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Abstract

We examined the effects of recombinant human thrombopoietin (rhTPO) on myelosuppressive chemotherapy-induced thrombocytopenia in cynomolgus monkeys. After treatment with nimustine (ACNU) on day 0, the monkeys intravenously received rhTPO at a dose of 0.04, 0.2 or 1 μg/kg/d or monkey's serum once each day from day 1 to day 2.8. Administration of rhTPO reduced the severity of thrombocytopenia and accelerated the rate of platelet recovery in a dose-dependent fashion. Treatment with the highest rhTPO dose completely prevented thrombocytopenia and stimulated a marked increase in platelet counts over the normal values. Animals treated with ACNU also became neutropenic and slightly anaemic. Administration of rhTPO following ACNU treatment significantly improved neutropenia with increasing doses of rhTPO, but had no effect on anaemia. Compared to the control animals, rhTP0-treated animals exhibited no significant-changes in several serum parameters, C-reactive protein concentration and some blood coagulation profiles within the study period. These results suggest a therapeutic efficacy of rhTPO in improving chemotherapy-induced thrombocytopenia.

Original languageEnglish
Pages (from-to)722-728
Number of pages7
JournalBritish Journal of Haematology
Volume94
Issue number4
DOIs
Publication statusPublished - 1996 Jan 1
Externally publishedYes

Keywords

  • Chemotherapy
  • Neutropenia
  • Primates
  • Thrombocytopenia
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

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    Akahori, H., Shibuya, K., Obuchi, M., Nishizawa, Y., Tsuji, A., Kabaya, K., Kusaka, M., Ohashi, H., Tsumura, H., Kato, T., & Miyazaki, H. (1996). Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. British Journal of Haematology, 94(4), 722-728. https://doi.org/10.1046/j.1365-2141.1996.d01-1842.x