Effect of running training on DMH-induced aberrant crypt foci in rat colon

Noriyuki Fuku, Masako Ochiai, Shin Terada, Eri Takai, Hitoshi Nakagama, Izumi Tabata

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Abstract

PURPOSE: We examined the effects of treadmill-running training on the induction of aberrant crypt foci (ACF), which is the first step of colon cancer induction, in the colonic mucosa of rats injected with 1,2-dimethylhydrazine (DMH). METHODS: Four-week-old F344 rats (N = 38) were randomly assigned to training (19 rats) and control (19 rats) groups. After a week, all rats were given DMH (20 mg·kg body weight) once a week for 2 wk. Running training was started at age 7 wk (speed: 10 m·min, 0% grade, 120 min·d, 5 d·wk). After 4 wk of training, the rats were sacrificed and the colon was removed, opened, and counted for ACF with 0.2% methylene blue staining. RESULTS: Running training resulted in lower body- (P < 0.01) and adipose fat weight (P < 0.05). The numbers of ACF and total AC were significantly lower in the running training group than in the control group (P < 0.05). The occurrences of one, three, and five aberrant crypts per focus were also significantly lower in the running training group than in the control group (P < 0.05). The ratios of total AC/ACF did not significantly differ between the running training and control groups. CONCLUSIONS: The results of the present investigation suggest that low-intensity running training inhibits the DMH-induced initiation of colon ACF development.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalMedicine and Science in Sports and Exercise
Volume39
Issue number1
DOIs
Publication statusPublished - 2007 Jan
Externally publishedYes

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Keywords

  • 1,2-dimethylhydrazine
  • ACF
  • Colon cancer
  • Exercise
  • Physical activity
  • Primary prevention

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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