Effect of sex hormones on rat liver cytosolic alcohol dehydrogenase activity

Saori Harada, Kaoru Tachiyashiki, Kazuhiko Imaizumi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Rat liver cytosolic alcohol dehydrogenase (ADH) activity is known to be significantly higher in females than in males. To elucidate a possible mechanism of sex difference in the ADH activities, we studied the in vivo effects of the administrations of β-estradiol, progesterone or testosterone, and castrations (orchiectomy and ovariectomy) on the ADH activities in male and female Sprague-Dawley adult rats. Furthermore, we studied the ADH activities in six liver portions of sham-operated male, orchiectomized male, and female rats. The ADH activities were higher in orchiectomized male rats than in sham-operated male rats. These results were observed in all liver portions. The administration of testosterone (5 mg/kg BW, twice a day for 7 d) to orchiectomized male rats significantly decreased ADH activities. The ADH activities in ovariectomized female rats were comparable with those in sham-operated female rats. The administration of β-estradiol (50 μg/kg BW, once every 2 d for 20 d) or progesterone (75 μg/kg BW, once every 2 d for 20 d) to rats increased the ADH activities in males more than in females. These results suggest that the inhibitory action of androgen and the slight facilitatory actions of progestin and estrogen are involved in the mechanism of sex difference in adult rat liver cytosolic ADH activity.

Original languageEnglish
Pages (from-to)625-639
Number of pages15
JournalJournal of Nutritional Science and Vitaminology
Volume44
Issue number5
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

sex hormones
Alcohol Dehydrogenase
alcohol dehydrogenase
Gonadal Steroid Hormones
liver
Liver
rats
Sex Characteristics
castration
Progesterone
Testosterone
gender differences
Estradiol
testosterone
estradiol
progesterone
Orchiectomy
Castration
Ovariectomy
Progestins

Keywords

  • Alcohol dehydrogenase
  • Castrations
  • Hormonal regulations of ethanol metabolism in rats
  • Sex hormones

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Effect of sex hormones on rat liver cytosolic alcohol dehydrogenase activity. / Harada, Saori; Tachiyashiki, Kaoru; Imaizumi, Kazuhiko.

In: Journal of Nutritional Science and Vitaminology, Vol. 44, No. 5, 1998, p. 625-639.

Research output: Contribution to journalArticle

Harada, Saori ; Tachiyashiki, Kaoru ; Imaizumi, Kazuhiko. / Effect of sex hormones on rat liver cytosolic alcohol dehydrogenase activity. In: Journal of Nutritional Science and Vitaminology. 1998 ; Vol. 44, No. 5. pp. 625-639.
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