Effect of somatostatin on circadian rhythms of firing and 2-deoxyglucose uptake in rat suprachiasmatic slices

T. Hamada, Shigenobu Shibata, A. Tsuneyoshi, K. Tominaga, S. Watanabe

Research output: Contribution to journalArticle

Abstract

In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus appears to act as a circadian clock. The SCN vasoactive intestinal polypeptide-like immunoreactive neurons, which may act to mediate photic information in the SCN, receive input from neurons immunoreactive for somatostatin (SST). Therefore we investigated the role of SST as a transmitter for entrainment by analyzing the phase-resetting effect of SST on the circadian rhythm of SCN firing activity. Perfusion of SST increased 2-deoxyglucose uptake at circadian time (CT) 18, but not at CT6. A 1-h or 15-min treatment with SST produced phase delays when it was administered at CT13-14 and phase advances at CT22-23. Thus SST-induced phase changes are similar to those for light pulses to animals under constant darkness. The present findings suggest that SST is a transmitter for mediating information of entrainment to circadian clocks within the SCN.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume265
Issue number5 34-5
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Deoxyglucose
Circadian Rhythm
Somatostatin
Suprachiasmatic Nucleus
Circadian Clocks
Neurons
Vasoactive Intestinal Peptide
Darkness
Hypothalamus
Mammals
Perfusion
Light

Keywords

  • brain slice
  • metabolic rhythm
  • peptide
  • phase-response curve

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of somatostatin on circadian rhythms of firing and 2-deoxyglucose uptake in rat suprachiasmatic slices. / Hamada, T.; Shibata, Shigenobu; Tsuneyoshi, A.; Tominaga, K.; Watanabe, S.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 265, No. 5 34-5, 1993.

Research output: Contribution to journalArticle

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AU - Shibata, Shigenobu

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AU - Watanabe, S.

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