Effect of spore-bearing lactic acid-forming bacteria (Bacillus coagulans SANK 70258) administration on the intestinal environment, defecation frequency, fecal characteristics and dermal characteristics in humans and rats

Katsutoshi Ara, Shinichi Meguro, Tadasi Hase, Ichirou Tokimitsu, Kazuya Otsuji, Shuji Kawai, Susumu Ito, Hisakazu Iino

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The effects of spore-bearing lactic acid-forming bacteria (Bacillus coagulans SANK 70258) on intestinal flora and decomposition products in the intestine, as well as on various dermal characteristics were determined in healthy humans and rats. Improvement of fecal shape, change of fecal color from dark brown to yellowish brown, decrease of fecal odor and fecal pH and an increase in defecation frequency in persons whose defecation frequency was relatively low were observed after administration. The number of intestinal bifidobacteria significantly (p < 0.05) increased, whereas the number of intestinal Clostridium perfringens significantly (p < 0.05) decreased after administration compared with the values before the intake. The concentrations of intestinal ammonia, indole and p-cresol decreased. The activities of β-glucuronidase and tryptophanase decreased significantly compared with the levels during the control period (p < 0.05). The spore-bearing lactic acid-forming bacilli group was given B. coagulans SANK 70258, while kept on a basic diet adjusted to 60% protein. Protein was supplied by casein. After removing back hair, the rats were exposed to radiation of UV-B 0.5 MED once a day. Two weeks after the start of radiation, measurements were made for the number of exanthema (the number of flare and papula). The number of exanthema decreased as constipation alleviated as a result of the intake of B. coagulans SANK 70258. In experiment 2, improvement of fecal shape, change of fecal color from dark brown to yellowish brown, decrease of fecal odor, the fecal pH and increase in defecation frequency of persons whose frequency was relatively low were observed after administration. The number of intestinal bifidobacteria significantly (p < 0.05) increased, whereas the number of intestinal C. perfringens significantly (p < 0.05) decreased after administration compared with the values before the intake. The concentrations of intestinal ammonia, indole and p-cresol content decreased. The activity of β-glucuronidase and tryptophanase decreased significantly (p < 0.05) compared with the levels during the control period. The number of comedones decreased as constipation was alleviated as a result of the intake of B. coagulans SANK 70258. These results indicate that the administration of B. coagulans SANK 70258 improves the intestinal environment, defecation frequency, fecal characteristics and dermal characteristics.

Original languageEnglish
Pages (from-to)4-13
Number of pages10
JournalMicrobial Ecology in Health and Disease
Volume14
Issue number1
DOIs
Publication statusPublished - 2002 Jan 1
Externally publishedYes

Fingerprint

Defecation
Spores
Lactic Acid
Bacteria
Tryptophanase
Skin
Clostridium perfringens
Bifidobacterium
Glucuronidase
Constipation
Exanthema
Ammonia
Color
Radiation
Caseins
Hair
Bacillus
Intestines
Proteins
Bacillus coagulans

Keywords

  • Bifidobacteria
  • Comedones
  • Dermal characteristics
  • Intestinal environment
  • Intestinal flora
  • Spore-forming lactobacillus

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Effect of spore-bearing lactic acid-forming bacteria (Bacillus coagulans SANK 70258) administration on the intestinal environment, defecation frequency, fecal characteristics and dermal characteristics in humans and rats. / Ara, Katsutoshi; Meguro, Shinichi; Hase, Tadasi; Tokimitsu, Ichirou; Otsuji, Kazuya; Kawai, Shuji; Ito, Susumu; Iino, Hisakazu.

In: Microbial Ecology in Health and Disease, Vol. 14, No. 1, 01.01.2002, p. 4-13.

Research output: Contribution to journalArticle

Ara, Katsutoshi ; Meguro, Shinichi ; Hase, Tadasi ; Tokimitsu, Ichirou ; Otsuji, Kazuya ; Kawai, Shuji ; Ito, Susumu ; Iino, Hisakazu. / Effect of spore-bearing lactic acid-forming bacteria (Bacillus coagulans SANK 70258) administration on the intestinal environment, defecation frequency, fecal characteristics and dermal characteristics in humans and rats. In: Microbial Ecology in Health and Disease. 2002 ; Vol. 14, No. 1. pp. 4-13.
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