Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats

R. Oishi, S. Watanabe, Shigenobu Shibata, S. Shibata, S. Ueki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Effects of stimulation of the locus coeruleus (LC) on evoked potential in the medial amygdala elicited by stimulation of the olfactory bulb (OB-AME potential) were studied in gallamine-immobilized rats. The amplitude of the OB-AME potential was inhibited 27.5% by the conditioning stimulation of LC delivered 30 msec before the test stimulation. The inhibitory effect of LC was reduced by propranolol 5 mg/kg i.p., but not by phentolamine 10 mg/kg i.p. This effect was also reduced by tetrabenazine 10 mg/kg i.p. Methamphetamine 5 mg/kg i.p. produced considerable potentiation of the LC inhibitory effect and a reduction of the OB-AME potential itself. These results suggest that the LC plays an inhibitory role in the electrical activity of the medial amygdala.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalJapanese Journal of Pharmacology
Volume29
Issue number1
Publication statusPublished - 1979
Externally publishedYes

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Locus Coeruleus
Amygdala
Evoked Potentials
Tetrabenazine
Gallamine Triethiodide
Methamphetamine
Phentolamine
Olfactory Bulb
Propranolol
methylamphotericin B

ASJC Scopus subject areas

  • Pharmacology

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Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats. / Oishi, R.; Watanabe, S.; Shibata, Shigenobu; Shibata, S.; Ueki, S.

In: Japanese Journal of Pharmacology, Vol. 29, No. 1, 1979, p. 105-111.

Research output: Contribution to journalArticle

Oishi, R. ; Watanabe, S. ; Shibata, Shigenobu ; Shibata, S. ; Ueki, S. / Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats. In: Japanese Journal of Pharmacology. 1979 ; Vol. 29, No. 1. pp. 105-111.
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