Effect of supersaturation on crystal size and number of crystals produced in antisolvent crystallization

Shogo Kaneko, Yasuhiro Yamagami, Heisuke Tochihara, Izumi Hirasawa

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    The antisolvent crystallization of sodium chloride was carried out in batches to observe crystallization phenomena using ethanol as an antisolvent. To decrease high local supersaturation generated by the addition of antisolvent, the authors have proposed a new idea by choosing high ethanol concentration operational conditions. Obtained crystals seemed to be unagglomerated and monodispersed in the optimum range of ethanol concentration. From the observation of nucleation phenomena, it was considered that nucleation induced by the antisolvent addition occurred due to the local supersaturation generated at the boundary of the starting and feed solutions. On the other hand, crystal growth is considered to proceed by the supersaturation generated by sufficient mixing between the starting and feed solutions. Average crystal size increased with the increase of σR. The number of produced crystals increased with the increase of the starting solution concentration C. The induction period for nucleation tended to decrease with increase of C and σR. Since the number of produced crystals depended on C, nucleation was considered to be influenced by local mixing between the starting and feed solutions.

    Original languageEnglish
    Pages (from-to)1219-1223
    Number of pages5
    JournalJournal of Chemical Engineering of Japan
    Volume35
    Issue number11
    DOIs
    Publication statusPublished - 2002 Nov

    Fingerprint

    Supersaturation
    Crystallization
    Nucleation
    Crystals
    Ethanol
    Sodium chloride
    Crystal growth
    Sodium Chloride

    Keywords

    • Antisolvent crystallization
    • Sodium chloride
    • Supersaturation

    ASJC Scopus subject areas

    • Chemical Engineering(all)

    Cite this

    Effect of supersaturation on crystal size and number of crystals produced in antisolvent crystallization. / Kaneko, Shogo; Yamagami, Yasuhiro; Tochihara, Heisuke; Hirasawa, Izumi.

    In: Journal of Chemical Engineering of Japan, Vol. 35, No. 11, 11.2002, p. 1219-1223.

    Research output: Contribution to journalArticle

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    abstract = "The antisolvent crystallization of sodium chloride was carried out in batches to observe crystallization phenomena using ethanol as an antisolvent. To decrease high local supersaturation generated by the addition of antisolvent, the authors have proposed a new idea by choosing high ethanol concentration operational conditions. Obtained crystals seemed to be unagglomerated and monodispersed in the optimum range of ethanol concentration. From the observation of nucleation phenomena, it was considered that nucleation induced by the antisolvent addition occurred due to the local supersaturation generated at the boundary of the starting and feed solutions. On the other hand, crystal growth is considered to proceed by the supersaturation generated by sufficient mixing between the starting and feed solutions. Average crystal size increased with the increase of σR. The number of produced crystals increased with the increase of the starting solution concentration C. The induction period for nucleation tended to decrease with increase of C and σR. Since the number of produced crystals depended on C, nucleation was considered to be influenced by local mixing between the starting and feed solutions.",
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    AU - Tochihara, Heisuke

    AU - Hirasawa, Izumi

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