Effect of supplement containing krill oil on serum lipids in Japanese - A randomized, double-blind, placebo-controlled study

Shuichi Fukumoto, Yoshiyuki Katsumata, Kazuhiko Yoshikawa, Kazuhiro Sakaida, Naoko Suzuki, Kazuo Yamamoto, Tsuyoshi Takara, Kazunaga Yazawa

Research output: Contribution to journalArticle

Abstract

Objectives: Krill oil is extracted from Euphausia superba. Krill oil that contains n-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is expected as ingredients to improve serum lipids. The purpose of this study was to verify ingestion of krill oil containing supplement makes serum lipids decrease in Japanese subjects. Methods: This test was carried out as a double-blind placebo-controlled randomized controlled trial. Japanese men and women whose ages were between 30 and 59 consumed soft capsules containing krill oil or placebo for 12 weeks, examine by variation of serum lipids in krill oil normal quantity group, krill oil 3-fold quantity group and placebo group. Blood was collected and tested prior to ingestion, after 4 weeks, 8 weeks, 12 weeks and 16 weeks (after 4 weeks to stop ingestion). Results: In the group who took krill oil supplement, triglyceride (TG) was significantly decreased after ingestion for 8 weeks. Also, HDL-cholesterol was significantly increased through administration period. Free fatty acids significantly decreased after 12-week ingestion. Conclusion: It is suggested that krill oil supplement is a useful food maintaining the TG to the proper value for Japanese adults.

Original languageEnglish
Pages (from-to)837-847
Number of pages11
JournalJapanese Pharmacology and Therapeutics
Volume43
Issue number6
Publication statusPublished - 2015

Fingerprint

Euphausiacea
Oils
Placebos
Lipids
Serum
Eating
Triglycerides
Eicosapentaenoic Acid
Docosahexaenoic Acids
Omega-3 Fatty Acids
Nonesterified Fatty Acids
HDL Cholesterol
Capsules
Randomized Controlled Trials

Keywords

  • Docosahexaenoic acid (DHA)
  • Eicosapentaenoic acid (EPA)
  • Krill oil
  • N-3 fatty acid
  • Triglyceride

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Fukumoto, S., Katsumata, Y., Yoshikawa, K., Sakaida, K., Suzuki, N., Yamamoto, K., ... Yazawa, K. (2015). Effect of supplement containing krill oil on serum lipids in Japanese - A randomized, double-blind, placebo-controlled study. Japanese Pharmacology and Therapeutics, 43(6), 837-847.

Effect of supplement containing krill oil on serum lipids in Japanese - A randomized, double-blind, placebo-controlled study. / Fukumoto, Shuichi; Katsumata, Yoshiyuki; Yoshikawa, Kazuhiko; Sakaida, Kazuhiro; Suzuki, Naoko; Yamamoto, Kazuo; Takara, Tsuyoshi; Yazawa, Kazunaga.

In: Japanese Pharmacology and Therapeutics, Vol. 43, No. 6, 2015, p. 837-847.

Research output: Contribution to journalArticle

Fukumoto, S, Katsumata, Y, Yoshikawa, K, Sakaida, K, Suzuki, N, Yamamoto, K, Takara, T & Yazawa, K 2015, 'Effect of supplement containing krill oil on serum lipids in Japanese - A randomized, double-blind, placebo-controlled study', Japanese Pharmacology and Therapeutics, vol. 43, no. 6, pp. 837-847.
Fukumoto, Shuichi ; Katsumata, Yoshiyuki ; Yoshikawa, Kazuhiko ; Sakaida, Kazuhiro ; Suzuki, Naoko ; Yamamoto, Kazuo ; Takara, Tsuyoshi ; Yazawa, Kazunaga. / Effect of supplement containing krill oil on serum lipids in Japanese - A randomized, double-blind, placebo-controlled study. In: Japanese Pharmacology and Therapeutics. 2015 ; Vol. 43, No. 6. pp. 837-847.
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