Effect of supplement containing Lactococcus lactis subsp. cremoris FC on defecation in healthy humans: A randomized, placebo-controlled, double-blind crossover trial

Toshiya Toda, Fumio Nanba, Kahei Arai, Naoko Takamizawa, Nobuhiko Shioya, Satoru Suzuki

Research output: Contribution to journalArticle

Abstract

Objectives The aim of this study was to evaluate the effect of Lactococcus lactis subsp. cremoris FC on fecal properties and fecal microflora in healthy subjects prone to constipation. Methods In total, 50 volunteers (seven men and 43 women) were randomized into two groups and given 100 mg of L. lactis subsp. cremoris FC (test) or dextrin (placebo) daily for 2 weeks in a double-blind, placebo-controlled, cross-over study. The fecal microflora was analyzed using the DNA extracted from feces and a real-time polymerase chain reaction. Results Compared with the ingestion of placebo, the defecation frequency significantly increased (days/week, P<0.05; times/week, P< 0.001) with the ingestion of L. lactis subsp. cremoris FC. The total bacterial count (log) and Lactobacillus sp. bacterial count (log) significantly (P<0.05) increased 2 weeks after the ingestion of test. Conclusion These results suggest that the continuous ingestion of L. lactis subsp. cremoris FC caused changes in intestinal microflora, improving defecation status and fecal characteristics in healthy subjects prone to constipation.

Original languageEnglish
Pages (from-to)989-997
Number of pages9
JournalJapanese Pharmacology and Therapeutics
Volume45
Issue number6
Publication statusPublished - 2017

Fingerprint

Lactococcus lactis
Defecation
Cross-Over Studies
Eating
Placebos
Bacterial Load
Constipation
Healthy Volunteers
Lactobacillus
Feces
Real-Time Polymerase Chain Reaction
Volunteers
DNA

Keywords

  • Defecation frequency
  • Double-blind placebo-controlled cross-over study
  • Intestinal microflora
  • Lactococcus lactis subsp. cremoris FC

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Effect of supplement containing Lactococcus lactis subsp. cremoris FC on defecation in healthy humans : A randomized, placebo-controlled, double-blind crossover trial. / Toda, Toshiya; Nanba, Fumio; Arai, Kahei; Takamizawa, Naoko; Shioya, Nobuhiko; Suzuki, Satoru.

In: Japanese Pharmacology and Therapeutics, Vol. 45, No. 6, 2017, p. 989-997.

Research output: Contribution to journalArticle

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