Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles

Lenitza Nieves, Christopher Hernandez, Jacob Lilly, Joey Mangadlao, Rigoberto Advincula, Agata Exner

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Microbubble (MB) contrast agents are widely used in diagnostic and therapeutic ultrasound (US) applications. However, due to their 1-10 μm size range, MBs have limited use in cancer detection and treatment. To expand contrast enhanced US capabilities, we have developed sub-micron contrast agents, nanobubbles (NB), via the addition of Pluronic, a nonionic triblock copolymer surfactant, to the phospholipid shell stabilizing perfluoropropane (C3F8) gas (Fig 1A). NBs, with diameter of ∼200nm, can take advantage of the EPR effect, extravasate the leaky tumor vasculature and accumulate in tumors. Prior work has shown that bubble echogenicity and stability are, in part, dependent on the surface tension of the stabilizing shell. In this study, we evaluate the effect of Pluronic on surface tension of the lipid films and how its presence in the NB shell affects echogenicity and signal decay at clinically-relevant imaging frequencies.

    Original languageEnglish
    Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
    PublisherIEEE Computer Society
    ISBN (Electronic)9781538633830
    DOIs
    Publication statusPublished - 2017 Oct 31
    Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
    Duration: 2017 Sep 62017 Sep 9

    Other

    Other2017 IEEE International Ultrasonics Symposium, IUS 2017
    CountryUnited States
    CityWashington
    Period17/9/617/9/9

    Fingerprint

    lipids
    surfactants
    interfacial tension
    tumors
    copolymers
    bubbles
    cancer
    decay
    gases

    ASJC Scopus subject areas

    • Acoustics and Ultrasonics

    Cite this

    Nieves, L., Hernandez, C., Lilly, J., Mangadlao, J., Advincula, R., & Exner, A. (2017). Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles. In 2017 IEEE International Ultrasonics Symposium, IUS 2017 [8092148] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2017.8092148

    Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles. / Nieves, Lenitza; Hernandez, Christopher; Lilly, Jacob; Mangadlao, Joey; Advincula, Rigoberto; Exner, Agata.

    2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017. 8092148.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nieves, L, Hernandez, C, Lilly, J, Mangadlao, J, Advincula, R & Exner, A 2017, Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles. in 2017 IEEE International Ultrasonics Symposium, IUS 2017., 8092148, IEEE Computer Society, 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 17/9/6. https://doi.org/10.1109/ULTSYM.2017.8092148
    Nieves L, Hernandez C, Lilly J, Mangadlao J, Advincula R, Exner A. Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles. In 2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society. 2017. 8092148 https://doi.org/10.1109/ULTSYM.2017.8092148
    Nieves, Lenitza ; Hernandez, Christopher ; Lilly, Jacob ; Mangadlao, Joey ; Advincula, Rigoberto ; Exner, Agata. / Effect of the surfactant pluronic on the stability of lipid-stabilized perfluorocarbon nanobubbles. 2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017.
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