Effect of transient vascular occlusion of the upper arm on motor evoked potentials during force exertion

Yudai Takarada, Yukari Ohki, Masato Taira

Research output: Contribution to journalArticle

Abstract

We previously observed that transient vascular occlusion in volunteers increased the estimation of force exertion with no change in peripheral nerves or muscles. We hypothesized that the primary factor responsible for the overestimation of force exertion during occlusion was the centrally generated motor command, as hypothesized by McCloskey et al. (1974) and McCloskey (1978, 1981). In the present study, we tested the hypothesis that transient vascular occlusion increases the excitability of the primary motor cortex (M1) during force exertion. Healthy human volunteers lay on a bed and squeezed a dynamometer in their right hand. Repetitive gripping forces were exerted at 20%, 40%, or 60% of maximum force, with or without transient (20. s) vascular occlusion of the proximal portion of the right upper arm. During the task, single-pulse transcranial magnetic stimulation was applied to the contralateral M1 to induce motor evoked potentials (MEPs) in the flexor carpi ulnaris (FCU) muscle. The MEP amplitudes were enhanced with occlusion under all conditions, with the exception of 60% contraction. In contrast, no significant difference was observed between the MEP amplitudes obtained from the occluded or non-occluded, relaxed FCU muscle. These results suggest that transient vascular occlusion increases the excitability of M1 only during force exertion.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalNeuroscience Research
Volume76
Issue number4
DOIs
Publication statusPublished - 2013 Aug 1

Keywords

  • Force perception
  • Primary motor cortex
  • Transcranial magnetic stimulation
  • Transient vascular occlusion

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Effect of transient vascular occlusion of the upper arm on motor evoked potentials during force exertion'. Together they form a unique fingerprint.

  • Cite this