Effect of Ultrasonic Irradiation on the Probability of Primary Nucleation of L-Arginine Hydrochloride

Research output: Contribution to journalArticlepeer-review

Abstract

Most of the amino acids that are utilized as medical raw materials and food additives show polymorphism. To improve the functionality of amino acid crystals, an effective method of polymorph control is required in the crystallization process. Here, primary nucleation of L-arginine hydrochloride by ultrasonication was investigated. L-Arginine hydrochloride exhibits polymorphism, and it crystallizes into three distinct crystal forms. A cooling crystallization experiment was performed, and nucleation of each polymorph upon ultrasonication was observed. In addition, the nucleation was analyzed using the nucleation probability theory. The results indicate that ultrasonic irradiation would significantly induce the nucleation of a particular polymorph.

Original languageEnglish
Pages (from-to)1099-1104
Number of pages6
JournalChemical Engineering and Technology
Volume43
Issue number6
DOIs
Publication statusPublished - 2020 Jun 1

Keywords

  • Amino acids
  • Crystallization
  • Nucleation
  • Polymorphism
  • Ultrasound

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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