Effect of ultrasonic irradiation on the selective polymorph control in sulfamerazine

Masahiro Kurotani, Izumi Hirasawa

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The selective polymorph control in sulfamerazine (SMZ) using ultrasonic irradiation was investigated. Firstly, the behavior of polymorphs in the absence of ultrasonic irradiation with various degrees of supersaturation was monitored. As a result, only metastable form-I crystallized at the primary nucleation stage and crystal growth of only form-I was recognized. The nucleation rate of stable form-II was very small, and the transformation from form-I to form-II hardly occurred. Therefore, it is easy to obtain form-I without ultrasonic irradiation, as it does not depend on the level of supersaturation. Secondly, the behavior of polymorphs with various degrees of ultrasonic energy and supersaturation was monitored. As a result, only form-I was obtained in the case of small ultrasonic energy. However, in addition to the nucleation of form-I, an unknown form-III and/or the recognized form-II are induced to nucleate under the influence of the ultrasonic energy in the case of large ultrasonic energy. Eventually, all forms changed to form-II within a short period of time. Therefore, polymorph control of SMZ can be achieved easily by supplying an appropriate amount of ultrasonic energy.

    Original languageEnglish
    Pages (from-to)1272-1278
    Number of pages7
    JournalChemical Engineering Research and Design
    Volume88
    Issue number9
    DOIs
    Publication statusPublished - 2010 Sep

    Fingerprint

    Sulfamerazine
    Polymorphism
    Ultrasonics
    Irradiation
    Supersaturation
    Nucleation
    Crystallization
    Crystal growth

    Keywords

    • Growth from solution
    • Nucleation
    • Organic compounds
    • Polymorphism
    • Ultrasonic irradiation

    ASJC Scopus subject areas

    • Chemical Engineering(all)
    • Chemistry(all)

    Cite this

    Effect of ultrasonic irradiation on the selective polymorph control in sulfamerazine. / Kurotani, Masahiro; Hirasawa, Izumi.

    In: Chemical Engineering Research and Design, Vol. 88, No. 9, 09.2010, p. 1272-1278.

    Research output: Contribution to journalArticle

    @article{302e61c808ac4d408a2a5c0d84936af8,
    title = "Effect of ultrasonic irradiation on the selective polymorph control in sulfamerazine",
    abstract = "The selective polymorph control in sulfamerazine (SMZ) using ultrasonic irradiation was investigated. Firstly, the behavior of polymorphs in the absence of ultrasonic irradiation with various degrees of supersaturation was monitored. As a result, only metastable form-I crystallized at the primary nucleation stage and crystal growth of only form-I was recognized. The nucleation rate of stable form-II was very small, and the transformation from form-I to form-II hardly occurred. Therefore, it is easy to obtain form-I without ultrasonic irradiation, as it does not depend on the level of supersaturation. Secondly, the behavior of polymorphs with various degrees of ultrasonic energy and supersaturation was monitored. As a result, only form-I was obtained in the case of small ultrasonic energy. However, in addition to the nucleation of form-I, an unknown form-III and/or the recognized form-II are induced to nucleate under the influence of the ultrasonic energy in the case of large ultrasonic energy. Eventually, all forms changed to form-II within a short period of time. Therefore, polymorph control of SMZ can be achieved easily by supplying an appropriate amount of ultrasonic energy.",
    keywords = "Growth from solution, Nucleation, Organic compounds, Polymorphism, Ultrasonic irradiation",
    author = "Masahiro Kurotani and Izumi Hirasawa",
    year = "2010",
    month = "9",
    doi = "10.1016/j.cherd.2010.02.014",
    language = "English",
    volume = "88",
    pages = "1272--1278",
    journal = "Chemical Engineering Research and Design",
    issn = "0263-8762",
    publisher = "Institution of Chemical Engineers",
    number = "9",

    }

    TY - JOUR

    T1 - Effect of ultrasonic irradiation on the selective polymorph control in sulfamerazine

    AU - Kurotani, Masahiro

    AU - Hirasawa, Izumi

    PY - 2010/9

    Y1 - 2010/9

    N2 - The selective polymorph control in sulfamerazine (SMZ) using ultrasonic irradiation was investigated. Firstly, the behavior of polymorphs in the absence of ultrasonic irradiation with various degrees of supersaturation was monitored. As a result, only metastable form-I crystallized at the primary nucleation stage and crystal growth of only form-I was recognized. The nucleation rate of stable form-II was very small, and the transformation from form-I to form-II hardly occurred. Therefore, it is easy to obtain form-I without ultrasonic irradiation, as it does not depend on the level of supersaturation. Secondly, the behavior of polymorphs with various degrees of ultrasonic energy and supersaturation was monitored. As a result, only form-I was obtained in the case of small ultrasonic energy. However, in addition to the nucleation of form-I, an unknown form-III and/or the recognized form-II are induced to nucleate under the influence of the ultrasonic energy in the case of large ultrasonic energy. Eventually, all forms changed to form-II within a short period of time. Therefore, polymorph control of SMZ can be achieved easily by supplying an appropriate amount of ultrasonic energy.

    AB - The selective polymorph control in sulfamerazine (SMZ) using ultrasonic irradiation was investigated. Firstly, the behavior of polymorphs in the absence of ultrasonic irradiation with various degrees of supersaturation was monitored. As a result, only metastable form-I crystallized at the primary nucleation stage and crystal growth of only form-I was recognized. The nucleation rate of stable form-II was very small, and the transformation from form-I to form-II hardly occurred. Therefore, it is easy to obtain form-I without ultrasonic irradiation, as it does not depend on the level of supersaturation. Secondly, the behavior of polymorphs with various degrees of ultrasonic energy and supersaturation was monitored. As a result, only form-I was obtained in the case of small ultrasonic energy. However, in addition to the nucleation of form-I, an unknown form-III and/or the recognized form-II are induced to nucleate under the influence of the ultrasonic energy in the case of large ultrasonic energy. Eventually, all forms changed to form-II within a short period of time. Therefore, polymorph control of SMZ can be achieved easily by supplying an appropriate amount of ultrasonic energy.

    KW - Growth from solution

    KW - Nucleation

    KW - Organic compounds

    KW - Polymorphism

    KW - Ultrasonic irradiation

    UR - http://www.scopus.com/inward/record.url?scp=77956169107&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=77956169107&partnerID=8YFLogxK

    U2 - 10.1016/j.cherd.2010.02.014

    DO - 10.1016/j.cherd.2010.02.014

    M3 - Article

    AN - SCOPUS:77956169107

    VL - 88

    SP - 1272

    EP - 1278

    JO - Chemical Engineering Research and Design

    JF - Chemical Engineering Research and Design

    SN - 0263-8762

    IS - 9

    ER -