Effect of vitamin E on learning and memory deficit in aged rats

Hirokatsu Takatsu, Kei Owada, Kouichi Abe, Masahiro Nakano, Shiro Urano

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a vitamin E-supplemented diet had their learning and memory functions assessed in comparison with the aged rats fed a normal diet using a Morris water maze test. Although normal aged rats showed very poor learning ability concerning the place of a platform in the water maze apparatus, the aged rats fed the vitamin E-supplemented diet learned the place with a marked speed in only 5 trials. After old animals showed the maximum learning ability, they were kept in a normal atmosphere for 48 h without a trial followed by an assessment of their memory function using the same apparatus. The vitamin E-supplementation to aged rats resulted in marked retention of their maximum memory function, although normal aged rats showed a significant memory loss of about 60%. Pyrroloquinoline quinone (PQQ), which increases in the production of nerve growth factor, and protects neurons, had a similar effect on cognitive function to that of vitamin E in the aged rats. These results suggest that vitamin E may improve cognitive deficit caused through aging by not only its neuro-protecting effect but an antioxidant efficacy.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalJournal of Nutritional Science and Vitaminology
Volume55
Issue number5
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Memory Disorders
Vitamin E
Learning
Aptitude
Diet
PQQ Cofactor
Water
Nerve Growth Factor
Atmosphere
Cognition
Antioxidants
Neurons

Keywords

  • Aged rat
  • Cognitive deficit
  • Learning
  • Memory
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effect of vitamin E on learning and memory deficit in aged rats. / Takatsu, Hirokatsu; Owada, Kei; Abe, Kouichi; Nakano, Masahiro; Urano, Shiro.

In: Journal of Nutritional Science and Vitaminology, Vol. 55, No. 5, 2009, p. 389-393.

Research output: Contribution to journalArticle

Takatsu, Hirokatsu ; Owada, Kei ; Abe, Kouichi ; Nakano, Masahiro ; Urano, Shiro. / Effect of vitamin E on learning and memory deficit in aged rats. In: Journal of Nutritional Science and Vitaminology. 2009 ; Vol. 55, No. 5. pp. 389-393.
@article{352e7dd8a77543f698dfbacbbedb82c6,
title = "Effect of vitamin E on learning and memory deficit in aged rats",
abstract = "In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a vitamin E-supplemented diet had their learning and memory functions assessed in comparison with the aged rats fed a normal diet using a Morris water maze test. Although normal aged rats showed very poor learning ability concerning the place of a platform in the water maze apparatus, the aged rats fed the vitamin E-supplemented diet learned the place with a marked speed in only 5 trials. After old animals showed the maximum learning ability, they were kept in a normal atmosphere for 48 h without a trial followed by an assessment of their memory function using the same apparatus. The vitamin E-supplementation to aged rats resulted in marked retention of their maximum memory function, although normal aged rats showed a significant memory loss of about 60{\%}. Pyrroloquinoline quinone (PQQ), which increases in the production of nerve growth factor, and protects neurons, had a similar effect on cognitive function to that of vitamin E in the aged rats. These results suggest that vitamin E may improve cognitive deficit caused through aging by not only its neuro-protecting effect but an antioxidant efficacy.",
keywords = "Aged rat, Cognitive deficit, Learning, Memory, Vitamin E",
author = "Hirokatsu Takatsu and Kei Owada and Kouichi Abe and Masahiro Nakano and Shiro Urano",
year = "2009",
doi = "10.3177/jnsv.55.389",
language = "English",
volume = "55",
pages = "389--393",
journal = "Journal of Nutritional Science and Vitaminology",
issn = "0301-4800",
publisher = "Center for Academic Publications Japan",
number = "5",

}

TY - JOUR

T1 - Effect of vitamin E on learning and memory deficit in aged rats

AU - Takatsu, Hirokatsu

AU - Owada, Kei

AU - Abe, Kouichi

AU - Nakano, Masahiro

AU - Urano, Shiro

PY - 2009

Y1 - 2009

N2 - In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a vitamin E-supplemented diet had their learning and memory functions assessed in comparison with the aged rats fed a normal diet using a Morris water maze test. Although normal aged rats showed very poor learning ability concerning the place of a platform in the water maze apparatus, the aged rats fed the vitamin E-supplemented diet learned the place with a marked speed in only 5 trials. After old animals showed the maximum learning ability, they were kept in a normal atmosphere for 48 h without a trial followed by an assessment of their memory function using the same apparatus. The vitamin E-supplementation to aged rats resulted in marked retention of their maximum memory function, although normal aged rats showed a significant memory loss of about 60%. Pyrroloquinoline quinone (PQQ), which increases in the production of nerve growth factor, and protects neurons, had a similar effect on cognitive function to that of vitamin E in the aged rats. These results suggest that vitamin E may improve cognitive deficit caused through aging by not only its neuro-protecting effect but an antioxidant efficacy.

AB - In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a vitamin E-supplemented diet had their learning and memory functions assessed in comparison with the aged rats fed a normal diet using a Morris water maze test. Although normal aged rats showed very poor learning ability concerning the place of a platform in the water maze apparatus, the aged rats fed the vitamin E-supplemented diet learned the place with a marked speed in only 5 trials. After old animals showed the maximum learning ability, they were kept in a normal atmosphere for 48 h without a trial followed by an assessment of their memory function using the same apparatus. The vitamin E-supplementation to aged rats resulted in marked retention of their maximum memory function, although normal aged rats showed a significant memory loss of about 60%. Pyrroloquinoline quinone (PQQ), which increases in the production of nerve growth factor, and protects neurons, had a similar effect on cognitive function to that of vitamin E in the aged rats. These results suggest that vitamin E may improve cognitive deficit caused through aging by not only its neuro-protecting effect but an antioxidant efficacy.

KW - Aged rat

KW - Cognitive deficit

KW - Learning

KW - Memory

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=71949128146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71949128146&partnerID=8YFLogxK

U2 - 10.3177/jnsv.55.389

DO - 10.3177/jnsv.55.389

M3 - Article

C2 - 19926923

AN - SCOPUS:71949128146

VL - 55

SP - 389

EP - 393

JO - Journal of Nutritional Science and Vitaminology

JF - Journal of Nutritional Science and Vitaminology

SN - 0301-4800

IS - 5

ER -