Effects and safety of a dietary supplement containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort - A randomized, double-blind, placebo-controlled, parallel-group comparison study

Naoko Takamizawa, Nobuhiko Shioya, Hiromasa Nagaoka, Takayuki Uchino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: The aim of this study was to evaluate the effect and safety of a dietary supplement (Kojun premium®) containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-II and who were not suffering from the disease, were randomly divided into two groups: the test product (chicken comb extract-containing supplement) group and the control product (placebo) group. Knee pain and discomfort were evaluated using a visual analogue scale (VAS). The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results: Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4-12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion: These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort.

Original languageEnglish
Pages (from-to)207-217
Number of pages11
JournalJapanese Pharmacology and Therapeutics
Volume44
Issue number2
Publication statusPublished - 2016

Fingerprint

Comb and Wattles
Hyaluronic Acid
Dietary Supplements
Chickens
Knee
Placebos
Safety
Pain
Visual Analog Scale
Knee Osteoarthritis
Hematologic Tests
Urine
Control Groups
Health

Keywords

  • Hyaluronic acid
  • Knee pain and discomfort
  • Kojun premium®

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

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abstract = "Objectives: The aim of this study was to evaluate the effect and safety of a dietary supplement (Kojun premium{\circledR}) containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-II and who were not suffering from the disease, were randomly divided into two groups: the test product (chicken comb extract-containing supplement) group and the control product (placebo) group. Knee pain and discomfort were evaluated using a visual analogue scale (VAS). The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results: Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4-12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion: These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort.",
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AU - Shioya, Nobuhiko

AU - Nagaoka, Hiromasa

AU - Uchino, Takayuki

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N2 - Objectives: The aim of this study was to evaluate the effect and safety of a dietary supplement (Kojun premium®) containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-II and who were not suffering from the disease, were randomly divided into two groups: the test product (chicken comb extract-containing supplement) group and the control product (placebo) group. Knee pain and discomfort were evaluated using a visual analogue scale (VAS). The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results: Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4-12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion: These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort.

AB - Objectives: The aim of this study was to evaluate the effect and safety of a dietary supplement (Kojun premium®) containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-II and who were not suffering from the disease, were randomly divided into two groups: the test product (chicken comb extract-containing supplement) group and the control product (placebo) group. Knee pain and discomfort were evaluated using a visual analogue scale (VAS). The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results: Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4-12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion: These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort.

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