Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia

Akira Ishiguro, Tatsutoshi Nakahata, Kenji Muraoka, Tahara Tomoyuki Tahara, Hiroshi Miyazaki, Takashi Kato, Yuji Inaba, Toshikazu Shimbo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Thrombopoietin (TPO), produced mainly in the liver, is a major regulator of platelet production. Serum TPO levels are generally increased in thrombocytopenia. We report a case of a 12-year-old boy with chronic severe thrombocytopenia, achondroplasia and nephritis. Severe chronic thrombocytopenia was found at 9 months of age. It was resistant to any treatment. Studies on megakaryocytic colonies in vitro revealed that the marrow cells responded well to TPO and no plasma inhibitor was found. Although hepatic function test results were normal, serum TPO levels in the patient (0.94 fmol/ml) were consistent with those in age-matched children (0.49 1.75 fmol/ml). Chronic thrombocytopenia requires individual evaluation before clinical trials with TPO.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalInternational Journal of Hematology
Volume66
Issue number1
Publication statusPublished - 1997 Jul
Externally publishedYes

Fingerprint

Achondroplasia
Thrombopoietin
Thrombocytopenia
Serum
Nephritis
Liver
Blood Platelets
Bone Marrow
Clinical Trials

Keywords

  • Achondroplasia
  • Megakaryocyte
  • Platelet
  • Thrombocytopenia
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

Cite this

Ishiguro, A., Nakahata, T., Muraoka, K., Tomoyuki Tahara, T., Miyazaki, H., Kato, T., ... Shimbo, T. (1997). Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia. International Journal of Hematology, 66(1), 99-102.

Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia. / Ishiguro, Akira; Nakahata, Tatsutoshi; Muraoka, Kenji; Tomoyuki Tahara, Tahara; Miyazaki, Hiroshi; Kato, Takashi; Inaba, Yuji; Shimbo, Toshikazu.

In: International Journal of Hematology, Vol. 66, No. 1, 07.1997, p. 99-102.

Research output: Contribution to journalArticle

Ishiguro, A, Nakahata, T, Muraoka, K, Tomoyuki Tahara, T, Miyazaki, H, Kato, T, Inaba, Y & Shimbo, T 1997, 'Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia', International Journal of Hematology, vol. 66, no. 1, pp. 99-102.
Ishiguro A, Nakahata T, Muraoka K, Tomoyuki Tahara T, Miyazaki H, Kato T et al. Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia. International Journal of Hematology. 1997 Jul;66(1):99-102.
Ishiguro, Akira ; Nakahata, Tatsutoshi ; Muraoka, Kenji ; Tomoyuki Tahara, Tahara ; Miyazaki, Hiroshi ; Kato, Takashi ; Inaba, Yuji ; Shimbo, Toshikazu. / Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia. In: International Journal of Hematology. 1997 ; Vol. 66, No. 1. pp. 99-102.
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