Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters

Keiko Tominaga, Shigenobu Shibata, Showa Ueki, Shigenori Watanabe

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

The effects of 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), buspirone and ipsapirone on wheel-running activity in hamsters were investigated in comparison with those of GABAA receptor agonist muscimol and benzodiazepine triazolam. Intraperitoneal administration of 8-OH-DPAT, buspirone, ipsapirone, muscimol and triazolam at circadian time (CT) 8 (CT 12; onset of activity) induced a significant phase advance of wheel-running activity under constant light conditions. However, administration of these drugs at other CT points did not induce phase changes. The administration of trifluoromethylphenylpiperazine (TFMPP), a 5-HT1B receptor agonist, at CT8 produced a small phase advance. The phase advance induced by 8-OH-DPAT was blocked by pretreatment with (-)-pindolol, a 5-HT1A receptor antagonist. In addition, 8-OH-DPAT, buspirone and SM3997 accelerated the rate of re-entrainment to an 8-h phase advance in the light-dark cycle. These observations suggest that 5-HT1A receptors in the brain participate in the regulation of the circadian rhythm of wheel-running activity in hamsters.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalEuropean Journal of Pharmacology
Volume214
Issue number1
DOIs
Publication statusPublished - 1992 Apr 7
Externally publishedYes

Keywords

  • 5-HT (5-hydroxytryptamine, serotonin)
  • 5-HT receptors
  • Circadian rhythm
  • Wheel-running rhythm

ASJC Scopus subject areas

  • Pharmacology

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