Effects of activity level and type of muscle on glucose transporter protein concentration

Kentaro Kawanaka, Mitsuru Higuchi, Hajime Ohmori, Shigeru Katsuta

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, we investigated the possibility that GLUT 4 protein concentration and mitochondrial enzyme activity is coregulated by muscle contractile activity. In the first experiment, male rats were trained by treadmill running or swimming for 3 wks and training effects in upper-and hind-limb muscle were investigated. Treadmill training program induced increases of 30% in citrate synthase activity, 51% in hexokinase activity, and 35% in GLUT 4 protein concentration in hind-limb soleus muscles without causing training effects in upperlimb epitrochlearis muscles. On the other hand, swimming training program induced increases of 67% in citrate synthase activity, 139% in hexokinase activity, and 89% in GLUT 4 protein concentration in epitrochlearis muscle without causing training effects in soleus muscles. These results suggest that muscle contractile activity which raises mitochondrial enzyme activity increases GLUT 4 protein concentration in skeletal muscle. In a second set of experiment, we investigated relationship between muscle GLUT 4 protein concentration and mitochondrial enzyme activity by use of the various type of rat muscles (soleus, plantaris, red gastrocnemius, white gastrocnemius, epitrochlearis and heart), which possese different contractile activity level. Significant correlation was observed between GLUT 4 protein concentration and citrate synthase activity among different muscles (r=0.936). They suggest that muscle GLUT 4 protein concentration and mitochondrial enzyme activity level may be coregulated according to muscle contractile activity level.

Original languageEnglish
Pages (from-to)269-276
Number of pages8
JournalJapanese Journal of Physical Fitness and Sports Medicine
Volume43
Issue number4
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Glucose Transporter Type 4
Facilitative Glucose Transport Proteins
Muscles
Skeletal Muscle
Citrate (si)-Synthase
Proteins
Hexokinase
Muscle Proteins
Enzymes
Education
Upper Extremity
Running
Extremities

Keywords

  • endurance training
  • GLUT 4 protein concentration
  • mitochondrial enzyme activity
  • muscle type

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of activity level and type of muscle on glucose transporter protein concentration. / Kawanaka, Kentaro; Higuchi, Mitsuru; Ohmori, Hajime; Katsuta, Shigeru.

In: Japanese Journal of Physical Fitness and Sports Medicine, Vol. 43, No. 4, 1994, p. 269-276.

Research output: Contribution to journalArticle

Kawanaka, Kentaro ; Higuchi, Mitsuru ; Ohmori, Hajime ; Katsuta, Shigeru. / Effects of activity level and type of muscle on glucose transporter protein concentration. In: Japanese Journal of Physical Fitness and Sports Medicine. 1994 ; Vol. 43, No. 4. pp. 269-276.
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