Effects of an upstream DNA curvature on the strength of HSV thymidine kinase promoter.

Takashi Ohyama, Y. Kadokawa, Y. Hirota

Research output: Contribution to journalArticle

Abstract

The effect of an upstream DNA curvature on the strength of the herpes simplex virus thymidine kinase (TK) promoter was investigated by employing luciferase assay. A set of double-stranded oligonucleotides, each with an unique DNA configuration, were synthesized and substituted into an upstream region of the promoter. It was revealed from the assay that both plane and space curves exerted a negative influence upon the strength of the promoter.

Original languageEnglish
Pages (from-to)67-68
Number of pages2
JournalNucleic acids symposium series
Issue number34
Publication statusPublished - 1995
Externally publishedYes

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