Effects of breaking sitting by standing and acute exercise on postprandial oxidative stress

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Abstract

Background: Sedentary behavior, which includes sitting and TV viewing, has been identified as an independent risk factor for type 2 diabetes and cardiovascular disease. Breaking sedentary behavior improves metabolic health such as postprandial glycaemia and insulinemia. However, the mechanisms underlying this effect are unclear. Objectives: Here, we examined whether breaking sitting by standing and acute exercise reduces postprandial oxidative stress. Patient and Methods: Fifteen participants performed 3 trials (sitting, standing, and exercise), each lasting 2 days, in a randomised order. On day one of sitting trial, participants sat in a chair. For the standing trial, the participants stood 6 times, for a 45-minute period each time. For the exercise trial, the participants walked or ran at approximately 60% of age-predicted maximum heart rate for 30 minutes. On day two of each trial, participants rested and consumed the standardised breakfast and lunch. Blood samples were collected in the morning and afternoon on day one, and fasting and at 2, 4, and 6 hours postprandially on day two. Results: The concentrations of serum derivatives of reactive oxygen metabolites (d-ROMs) measured at 4 hours (P = 0.064) and 6 hours (P = 0.071) tended to be higher than that in the fasting state in the sitting trial, but not standing and exercise trial (two-factor analysis of variance (ANOVA), trial × time interaction, P = 0.006). Conclusions: Our results indicate the importance of reducing sitting time for improving postprandial oxidative stress status.

Original languageEnglish
Article numbere24902
JournalAsian Journal of Sports Medicine
Volume6
Issue number3
DOIs
Publication statusPublished - 2015 Sep 1

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Oxidative Stress
Exercise
Fasting
Lunch
Breakfast
Type 2 Diabetes Mellitus
Statistical Factor Analysis
Analysis of Variance
Cardiovascular Diseases
Heart Rate
Oxygen
Health
Serum

Keywords

  • Cardiovascular disease
  • Physical activity
  • Postprandial period
  • Redox
  • Sedentary lifestyle

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

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title = "Effects of breaking sitting by standing and acute exercise on postprandial oxidative stress",
abstract = "Background: Sedentary behavior, which includes sitting and TV viewing, has been identified as an independent risk factor for type 2 diabetes and cardiovascular disease. Breaking sedentary behavior improves metabolic health such as postprandial glycaemia and insulinemia. However, the mechanisms underlying this effect are unclear. Objectives: Here, we examined whether breaking sitting by standing and acute exercise reduces postprandial oxidative stress. Patient and Methods: Fifteen participants performed 3 trials (sitting, standing, and exercise), each lasting 2 days, in a randomised order. On day one of sitting trial, participants sat in a chair. For the standing trial, the participants stood 6 times, for a 45-minute period each time. For the exercise trial, the participants walked or ran at approximately 60{\%} of age-predicted maximum heart rate for 30 minutes. On day two of each trial, participants rested and consumed the standardised breakfast and lunch. Blood samples were collected in the morning and afternoon on day one, and fasting and at 2, 4, and 6 hours postprandially on day two. Results: The concentrations of serum derivatives of reactive oxygen metabolites (d-ROMs) measured at 4 hours (P = 0.064) and 6 hours (P = 0.071) tended to be higher than that in the fasting state in the sitting trial, but not standing and exercise trial (two-factor analysis of variance (ANOVA), trial × time interaction, P = 0.006). Conclusions: Our results indicate the importance of reducing sitting time for improving postprandial oxidative stress status.",
keywords = "Cardiovascular disease, Physical activity, Postprandial period, Redox, Sedentary lifestyle",
author = "Masaki Takahashi and Masashi Miyashita and Park, {Jong Hwan} and Shizuo Sakamoto and Katsuhiko Suzuki",
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T1 - Effects of breaking sitting by standing and acute exercise on postprandial oxidative stress

AU - Takahashi, Masaki

AU - Miyashita, Masashi

AU - Park, Jong Hwan

AU - Sakamoto, Shizuo

AU - Suzuki, Katsuhiko

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Background: Sedentary behavior, which includes sitting and TV viewing, has been identified as an independent risk factor for type 2 diabetes and cardiovascular disease. Breaking sedentary behavior improves metabolic health such as postprandial glycaemia and insulinemia. However, the mechanisms underlying this effect are unclear. Objectives: Here, we examined whether breaking sitting by standing and acute exercise reduces postprandial oxidative stress. Patient and Methods: Fifteen participants performed 3 trials (sitting, standing, and exercise), each lasting 2 days, in a randomised order. On day one of sitting trial, participants sat in a chair. For the standing trial, the participants stood 6 times, for a 45-minute period each time. For the exercise trial, the participants walked or ran at approximately 60% of age-predicted maximum heart rate for 30 minutes. On day two of each trial, participants rested and consumed the standardised breakfast and lunch. Blood samples were collected in the morning and afternoon on day one, and fasting and at 2, 4, and 6 hours postprandially on day two. Results: The concentrations of serum derivatives of reactive oxygen metabolites (d-ROMs) measured at 4 hours (P = 0.064) and 6 hours (P = 0.071) tended to be higher than that in the fasting state in the sitting trial, but not standing and exercise trial (two-factor analysis of variance (ANOVA), trial × time interaction, P = 0.006). Conclusions: Our results indicate the importance of reducing sitting time for improving postprandial oxidative stress status.

AB - Background: Sedentary behavior, which includes sitting and TV viewing, has been identified as an independent risk factor for type 2 diabetes and cardiovascular disease. Breaking sedentary behavior improves metabolic health such as postprandial glycaemia and insulinemia. However, the mechanisms underlying this effect are unclear. Objectives: Here, we examined whether breaking sitting by standing and acute exercise reduces postprandial oxidative stress. Patient and Methods: Fifteen participants performed 3 trials (sitting, standing, and exercise), each lasting 2 days, in a randomised order. On day one of sitting trial, participants sat in a chair. For the standing trial, the participants stood 6 times, for a 45-minute period each time. For the exercise trial, the participants walked or ran at approximately 60% of age-predicted maximum heart rate for 30 minutes. On day two of each trial, participants rested and consumed the standardised breakfast and lunch. Blood samples were collected in the morning and afternoon on day one, and fasting and at 2, 4, and 6 hours postprandially on day two. Results: The concentrations of serum derivatives of reactive oxygen metabolites (d-ROMs) measured at 4 hours (P = 0.064) and 6 hours (P = 0.071) tended to be higher than that in the fasting state in the sitting trial, but not standing and exercise trial (two-factor analysis of variance (ANOVA), trial × time interaction, P = 0.006). Conclusions: Our results indicate the importance of reducing sitting time for improving postprandial oxidative stress status.

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KW - Redox

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