Effects of centrally and systemically administered indomethacin on body temperature in exercising rats

H. Tanaka, M. Yanase-Fujiwara, Kazuyuki Kanosue

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Subcutaneous and intracerebroventricular (icv) injections of indomethacin were used to test whether prostaglandin synthesis is essential for the exercise-induced increase in a rat's body temperature. At an air temperature of 24°C , male Wistar rats ran on a treadmill at 10-15 m/min 20 min after 300-μg icv injection or 60 min after 15-mg/kg sc injection of indomethacin or of control vehicle. The rectal temperature (T(re)) of control rats in 17 control experiments increased by 1.0°C during exercise, whereas the T(re) of the rats pretreated with intracerebroventricular indomethacin increased by only 0.4°C. Threshold T(re) for tail vasodilation was significantly lower in rats pretreated with indomethacin than the control rats (38.4 ± 0.1 vs. 38.9 ± 0.1°C), but O2 uptake did not differ between indomethacin-pretreated and control rats. Subcutaneous injection of indomethacin did not affect the body temperature, tail vasomotor activity, or O2 uptake of exercising rats. Intracerebroventricular indomethacin did not affect T(re) or tail vasomotor activity of rats resting at ambient temperatures of 24 and 28°C. Present results suggest that prostaglandin synthesis is required for the vasoconstrictive effect of exercise on skin blood vessels and thus for the exercise-induced elevation of body temperature.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume265
Issue number1 34-1
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Body Temperature
Indomethacin
Temperature
Tail
Subcutaneous Injections
Prostaglandins
Injections
Vasodilation
Blood Vessels
Wistar Rats
Air
Skin

Keywords

  • intracerebroventricular indomethacin
  • prostaglandins

ASJC Scopus subject areas

  • Physiology

Cite this

@article{5a5a6e6534334e03a56964f25a7e03a9,
title = "Effects of centrally and systemically administered indomethacin on body temperature in exercising rats",
abstract = "Subcutaneous and intracerebroventricular (icv) injections of indomethacin were used to test whether prostaglandin synthesis is essential for the exercise-induced increase in a rat's body temperature. At an air temperature of 24°C , male Wistar rats ran on a treadmill at 10-15 m/min 20 min after 300-μg icv injection or 60 min after 15-mg/kg sc injection of indomethacin or of control vehicle. The rectal temperature (T(re)) of control rats in 17 control experiments increased by 1.0°C during exercise, whereas the T(re) of the rats pretreated with intracerebroventricular indomethacin increased by only 0.4°C. Threshold T(re) for tail vasodilation was significantly lower in rats pretreated with indomethacin than the control rats (38.4 ± 0.1 vs. 38.9 ± 0.1°C), but O2 uptake did not differ between indomethacin-pretreated and control rats. Subcutaneous injection of indomethacin did not affect the body temperature, tail vasomotor activity, or O2 uptake of exercising rats. Intracerebroventricular indomethacin did not affect T(re) or tail vasomotor activity of rats resting at ambient temperatures of 24 and 28°C. Present results suggest that prostaglandin synthesis is required for the vasoconstrictive effect of exercise on skin blood vessels and thus for the exercise-induced elevation of body temperature.",
keywords = "intracerebroventricular indomethacin, prostaglandins",
author = "H. Tanaka and M. Yanase-Fujiwara and Kazuyuki Kanosue",
year = "1993",
language = "English",
volume = "265",
journal = "American Journal of Physiology",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "1 34-1",

}

TY - JOUR

T1 - Effects of centrally and systemically administered indomethacin on body temperature in exercising rats

AU - Tanaka, H.

AU - Yanase-Fujiwara, M.

AU - Kanosue, Kazuyuki

PY - 1993

Y1 - 1993

N2 - Subcutaneous and intracerebroventricular (icv) injections of indomethacin were used to test whether prostaglandin synthesis is essential for the exercise-induced increase in a rat's body temperature. At an air temperature of 24°C , male Wistar rats ran on a treadmill at 10-15 m/min 20 min after 300-μg icv injection or 60 min after 15-mg/kg sc injection of indomethacin or of control vehicle. The rectal temperature (T(re)) of control rats in 17 control experiments increased by 1.0°C during exercise, whereas the T(re) of the rats pretreated with intracerebroventricular indomethacin increased by only 0.4°C. Threshold T(re) for tail vasodilation was significantly lower in rats pretreated with indomethacin than the control rats (38.4 ± 0.1 vs. 38.9 ± 0.1°C), but O2 uptake did not differ between indomethacin-pretreated and control rats. Subcutaneous injection of indomethacin did not affect the body temperature, tail vasomotor activity, or O2 uptake of exercising rats. Intracerebroventricular indomethacin did not affect T(re) or tail vasomotor activity of rats resting at ambient temperatures of 24 and 28°C. Present results suggest that prostaglandin synthesis is required for the vasoconstrictive effect of exercise on skin blood vessels and thus for the exercise-induced elevation of body temperature.

AB - Subcutaneous and intracerebroventricular (icv) injections of indomethacin were used to test whether prostaglandin synthesis is essential for the exercise-induced increase in a rat's body temperature. At an air temperature of 24°C , male Wistar rats ran on a treadmill at 10-15 m/min 20 min after 300-μg icv injection or 60 min after 15-mg/kg sc injection of indomethacin or of control vehicle. The rectal temperature (T(re)) of control rats in 17 control experiments increased by 1.0°C during exercise, whereas the T(re) of the rats pretreated with intracerebroventricular indomethacin increased by only 0.4°C. Threshold T(re) for tail vasodilation was significantly lower in rats pretreated with indomethacin than the control rats (38.4 ± 0.1 vs. 38.9 ± 0.1°C), but O2 uptake did not differ between indomethacin-pretreated and control rats. Subcutaneous injection of indomethacin did not affect the body temperature, tail vasomotor activity, or O2 uptake of exercising rats. Intracerebroventricular indomethacin did not affect T(re) or tail vasomotor activity of rats resting at ambient temperatures of 24 and 28°C. Present results suggest that prostaglandin synthesis is required for the vasoconstrictive effect of exercise on skin blood vessels and thus for the exercise-induced elevation of body temperature.

KW - intracerebroventricular indomethacin

KW - prostaglandins

UR - http://www.scopus.com/inward/record.url?scp=0027218150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027218150&partnerID=8YFLogxK

M3 - Article

VL - 265

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0193-1849

IS - 1 34-1

ER -